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Artículo

Chronic lymphocytic leukemia cells increase neutrophils survival and promote their differentiation into CD16 high CD62L dim immunosuppressive subset

Podaza, Enrique ArturoIcon ; Risnik, Denise MarielIcon ; Colado, AnaIcon ; Elías, Esteban EnriqueIcon ; Almejún, María BelénIcon ; Fernandez Grecco, Horacio; Bezares, Raimundo Fernando; Borge, MercedesIcon ; Gamberale, RominaIcon ; Giordano, Mirta NildaIcon
Fecha de publicación: 09/2019
Editorial: John Wiley & Sons Inc
Revista: International Journal of Cancer. Journal International du Cancer
ISSN: 0020-7136
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Reprogramming of neutrophils by malignant cells is well-described for many types of solid tumors, but data remain scarce for hematological diseases. Chronic lymphocytic leukemia (CLL) is characterized for a deep immune dysregulation mediated by leukemic cells that compromises patient´s outcome. Murine models of CLL highlight the relevance of myeloid cells as tumor-driven reprogramming targets. In our study, we evaluated neutrophil reprogramming by CLL cells. We first show that the proportion of the CD16high CD62Ldim neutrophil subset in peripheral blood of CLL patients is increased compared to age-matched healthy donors (HD). In vitro, neutrophils from HD cultured in the presence of CLL cells or conditioned media (CM) from CLL cells exhibited a longer lifespan. Depletion of G-CSF and GM-CSF from CM partially reversed the protective effect. In addition, the proportion of viable neutrophils that displayed a CD16high CD62Ldim phenotype was increased in the presence of CM from CLL cells, being TGF-β/IL-10 responsible for this effect. Altogether, our results describe a novel mechanism through which CLL cells can manipulate neutrophils.
Palabras clave: TUMOR ASSOCIATED NEUTROPHILS , APOPTOSIS , REPROGRAMMING
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/103571
DOI: http://dx.doi.org/10.1002/ijc.31762
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.31762
Colecciones
Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Podaza, Enrique Arturo; Risnik, Denise Mariel; Colado, Ana; Elías, Esteban Enrique; Almejún, María Belén; et al.; Chronic lymphocytic leukemia cells increase neutrophils survival and promote their differentiation into CD16 high CD62L dim immunosuppressive subset; John Wiley & Sons Inc; International Journal of Cancer. Journal International du Cancer; 144; 5; 9-2019; 1128-1134
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