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dc.contributor.author
de la Fuente, J.
dc.contributor.author
Massung, R. F.
dc.contributor.author
Wong, S. J.
dc.contributor.author
Chu, F. K.
dc.contributor.author
Lutz, H.
dc.contributor.author
Meli, M.
dc.contributor.author
von Loewenich, F. D.
dc.contributor.author
Grzeszczuk, A.
dc.contributor.author
Torina, A.
dc.contributor.author
Caracappa, S.
dc.contributor.author
Mangold, Atilio Jose
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dc.contributor.author
Naranjo, Ana Verónica
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dc.contributor.author
Stuen, S.
dc.contributor.author
Kocan, K. M.
dc.date.available
2020-04-23T15:04:08Z
dc.date.issued
2005-03
dc.identifier.citation
de la Fuente, J.; Massung, R. F.; Wong, S. J.; Chu, F. K.; Lutz, H.; et al.; Sequence Analysis of the msp4 Gene of Anaplasma phagocytophilum Strains; American Society for Microbiology; Journal of Clinical Microbiology; 43; 3; 3-2005; 1309-1317
dc.identifier.issn
0095-1137
dc.identifier.uri
http://hdl.handle.net/11336/103440
dc.description.abstract
The causative agent of human granulocytic ehrlichiosis was recently reclassified as Anaplasma phagocytophilum, unifying previously described bacteria that cause disease in humans, horses, dogs, and ruminants. For the characterization of genetic heterogeneity in this species, the homologue of Anaplasma marginale major surface protein 4 gene (msp4) was identified, and the coding region was PCR amplified and sequenced from a variety of sources, including 50 samples from the United States, Germany, Poland, Norway, Italy, and Switzerland and 4 samples of A. phagocytophilum-like organisms obtained from white-tailed deer in the United States. Sequence variation between strains of A. phagocytophilum (90 to 100% identity at the nucleotide level and 92 to 100% similarity at the protein level) was higher than in A. marginale. Phylogenetic analyses of msp4 sequences did not provide phylogeographic information but did differentiate strains of A. phagocytophilum obtained from ruminants from those obtained from humans, dogs, and horses. The sequence analysis of the recently discovered A. phagocytophilum msp2 gene corroborated these results. The results reported here suggest that although A. phagocytophilum-like organisms from white-tailed deer may be closely related to A. phagocytophilum, they could be more diverse. These results suggest that A. phagocytophilum strains from ruminants could share some common characteristics, including reservoirs and pathogenicity, which may be different from strains that infect humans.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Sequence Analysis of the msp4 Gene of Anaplasma phagocytophilum Strains
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-13T13:16:55Z
dc.journal.volume
43
dc.journal.number
3
dc.journal.pagination
1309-1317
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: de la Fuente, J.. Consejo Superior de Investigaciones Científicas; España. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Massung, R. F.. Centers for Disease Control and Prevention; Estados Unidos
dc.description.fil
Fil: Wong, S. J.. Wadsworth Center; Estados Unidos
dc.description.fil
Fil: Chu, F. K.. Wadsworth Center for Laboratories and Research; Estados Unidos
dc.description.fil
Fil: Lutz, H.. University of Zurich; Suiza
dc.description.fil
Fil: Meli, M.. University of Zurich; Suiza
dc.description.fil
Fil: von Loewenich, F. D.. University Clinic of Freiburg; Alemania
dc.description.fil
Fil: Grzeszczuk, A.. Medical University of Bialystok; Polonia
dc.description.fil
Fil: Torina, A.. Istituto Zooprofilattico Sperimentale della Sicilia; Italia
dc.description.fil
Fil: Caracappa, S.. Istituto Zooprofilattico Sperimentale della Sicilia; Italia
dc.description.fil
Fil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Naranjo, Ana Verónica. Instituto de Investigación en Recursos Cinegéticos; España
dc.description.fil
Fil: Stuen, S.. Norwegian School of Veterinary Science; Noruega
dc.description.fil
Fil: Kocan, K. M.. Oklahoma State University; Estados Unidos
dc.journal.title
Journal of Clinical Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/JCM.43.3.1309-1317.2005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jcm.asm.org/content/43/3/1309.long
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