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dc.contributor.author
van Uden, M. J.  
dc.contributor.author
Bonetto, Fernando Jose  
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ter Voert, E.  
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Orzada, S.  
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de Vries, J.  
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van Laarhoven, H.  
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Heerschap, A.  
dc.date.available
2020-04-22T21:55:53Z  
dc.date.issued
2011-05  
dc.identifier.citation
van Uden, M. J.; Bonetto, Fernando Jose; ter Voert, E.; Orzada, S.; de Vries, J.; et al.; 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.; John Wiley & Sons Inc; Proceedings of the International Society for Magnetic Resonance in Medicine; 19; 5-2011; 1901-1901  
dc.identifier.issn
1065-9889  
dc.identifier.uri
http://hdl.handle.net/11336/103382  
dc.description.abstract
RF excitation and reception offers advantages for absolute quantification of metabolites, drugs and cells in vivo. Capecitabine is a drug taken orally for treatment of liver metastasis in colorectal cancer. It is a prodrug that is preferentially converted to active metabolites in tumor tissue and further catabolized in the liver. Since capecitabine and its metabolites contain a fluorine atom it is possible to assess their distribution in healthy liver tissue and in liver metastases by 19F MRS. Monitoring and quantification of cells, applied therapeutically, in vivo is of major importance to estimate treatment efficacy. It has been demonstrated that combined 1H and 19F MRI allows for positive localization of cells and their quantification directly from image data, in a noninvasive way, without using radio-isotopes. Here we present a new coil setup that is capable of creating a homogeneous transmit RF-field for 19F and 1H in combination with dedicated receive coils for lymph nodes and for the liver to enable drug and cellular monitoring.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
John Wiley & Sons Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
19F MRI  
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Coils for magnetic homogeneity  
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Cell tracking  
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Tecnología de Laboratorios Médicos  
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Ingeniería Médica  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-04-21T15:19:04Z  
dc.journal.volume
19  
dc.journal.pagination
1901-1901  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Hoboken  
dc.description.fil
Fil: van Uden, M. J.. Radboud University Nijmegen Medical Center; Países Bajos  
dc.description.fil
Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.description.fil
Fil: ter Voert, E.. Radboud University Nijmegen Medical Center; Países Bajos  
dc.description.fil
Fil: Orzada, S.. Radboud University Nijmegen Medical Center; Países Bajos  
dc.description.fil
Fil: de Vries, J.. Nijmegen Center For Molecular Life Sciences; Países Bajos  
dc.description.fil
Fil: van Laarhoven, H.. Radboud University Nijmegen Medical Center; Países Bajos  
dc.description.fil
Fil: Heerschap, A.. Radboud University Nijmegen Medical Center; Países Bajos  
dc.journal.title
Proceedings of the International Society for Magnetic Resonance in Medicine