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dc.contributor.author
Potikha, Tamara
dc.contributor.author
Pappo, Orit
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Mizrahi, Lina
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Olam, Devorah
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Maller, Sebastián M.
dc.contributor.author
Rabinovich, Gabriel Adrián
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dc.contributor.author
Galun, Eithan
dc.contributor.author
Goldenberg, Daniel S.
dc.date.available
2020-04-22T19:55:28Z
dc.date.issued
2019-03
dc.identifier.citation
Potikha, Tamara; Pappo, Orit; Mizrahi, Lina; Olam, Devorah; Maller, Sebastián M.; et al.; Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model; Federation of American Societies for Experimental Biology; FASEB Journal; 33; 7; 3-2019; 1-13
dc.identifier.issn
0892-6638
dc.identifier.uri
http://hdl.handle.net/11336/103343
dc.description.abstract
Chronic liver inflammation (CLI) is a risk factor for development of hepatocellular carcinoma (HCC). Galectin-1 (Gal1) is involved in the regulation of inflammation, angiogenesis, and tumorigenesis, exhibiting multiple anti-inflammatory and protumorigenic activities. We aimed to explore its regulatory role in CLI and HCC progression using an established model of CLI-mediated HCC development, Abcb4 [multidrug-resistance 2 (Mdr2)]-knockout (KO) mice, which express high levels of Gal1 in the liver. We generated double-KO (dKO) Gal1- KO/Mdr2-KO mice on C57BL/6 and FVB/N genetic backgrounds and compared HCC development in the generated strains with their parentalMdr2-KO strains. Loss of Gal1 increased liver injury, inflammation, fibrosis, and ductular reaction in dKO mice of both strains starting from an early age. Aged dKO mutants displayed earlier hepatocarcinogenesis and increased tumor size compared with control Mdr2-KO mice. We found that osteopontin, a well-knownmodulator of HCC development, and oncogenic proteins Ntrk2 (TrkB) and S100A4 were overexpressed in dKO compared with Mdr2-KO livers. Our results demonstrate that in Mdr2-KO mice, a model of CLI-mediated HCC, Gal1-mediated protection from hepatitis, liver fibrosis, and HCC initiation dominates over its known procarcinogenic activities at later stages of HCC development. These findings suggest that anti-Gal1 treatmentsmay not be applicable at all stages of CLI-mediated HCC.—Potikha, T., Pappo, O., Mizrahi, L., Olam, D., Maller, S. M., Rabinovich, G. A., Galun, E., Goldenberg, D. S. Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Federation of American Societies for Experimental Biology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HEPATOCARCINOGÉNESIS
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INFLAMMATION
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LIVER
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FIBROSIS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-22T15:32:38Z
dc.journal.volume
33
dc.journal.number
7
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Potikha, Tamara. Universidad Academica de Hadassa Jerusalem; Israel
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Fil: Pappo, Orit. Universidad Academica de Hadassa Jerusalem; Israel
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Fil: Mizrahi, Lina. Universidad Academica de Hadassa Jerusalem; Israel
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Fil: Olam, Devorah. Universidad Academica de Hadassa Jerusalem; Israel
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Fil: Maller, Sebastián M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Galun, Eithan. Universidad Academica de Hadassa Jerusalem; Israel
dc.description.fil
Fil: Goldenberg, Daniel S.. Universidad Academica de Hadassa Jerusalem; Israel
dc.journal.title
FASEB Journal
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/10.1096/fj.201900017R
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1096/fj.201900017R
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