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dc.contributor.author
Campoy, Emanuel Martin
dc.contributor.author
Laurito, Sergio Roberto
dc.contributor.author
Urrutia, Guillermo
dc.contributor.author
Branham, Maria Teresita
dc.contributor.author
Roque Moreno, Maria
dc.date.available
2016-12-27T19:48:26Z
dc.date.issued
2013-08
dc.identifier.citation
Campoy, Emanuel Martin; Laurito, Sergio Roberto; Urrutia, Guillermo; Branham, Maria Teresita; Roque Moreno, Maria; Aberrant DNA methylation in breast cancer cells; S. Karger AG Medical and Scientific Publishers; Medical Epigenetics; 1; 1; 8-2013; 88-92
dc.identifier.issn
1664-5561
dc.identifier.uri
http://hdl.handle.net/11336/10330
dc.description.abstract
The epigenome is regulated by a large number of macromolecular machines that are dynamically involved in various processes, including DNA methylation, histone modification and non-coding RNA signals, all of them working together to regulate the proper expression of the genome. Thus, in contrast with the genome, whose sequence is carefully conserved during cell life, the epigenome is highly dynamic. The epigenomic modifications are acquired during normal cell differentiation, replicated during mitosis and passed to daughter cells. A fundamental epigenetic attribute is that this plasticity occurs in response to environmental signals. It is therefore now accepted that the environment influences modifications in the cellular transcriptome through the epigenome. In developmental and evolutionary terms, the regulation of gene expression through epigenomic modifications is an advantageous shortcut and a highly conserved mechanism. However, it implies an increased risk for misregulation, as, for example, aberrant epigenomic modifications associate with the development of different human diseases, i.e. lupus, asthma, neurological diseases and cancer. Although epigenetic alterations in breast cancer have been deeply studied and discussed in the last decades, apparently contradictory results are yet often observed. Consequently, in this review, we will briefly discuss the latest findings of aberrant DNA methylation in breast tumorigenesis. Emphasis will be given to the discussion of the idea that different environments could explain paradoxical biological and pathobiological behaviors in individual patients and thus should be taken into consideration for the design and implementation of diagnosis, prognosis and predictive biomarkers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
S. Karger AG Medical and Scientific Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aberrant Methylation
dc.subject
Breast Cancer
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Cancer Related Genes
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Aberrant DNA methylation in breast cancer cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-19T18:48:06Z
dc.journal.volume
1
dc.journal.number
1
dc.journal.pagination
88-92
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Campoy, Emanuel Martin. Consejo Nacional de Investigaciones Científicas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina
dc.description.fil
Fil: Laurito, Sergio Roberto. Consejo Nacional de Investigaciones Científicas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina
dc.description.fil
Fil: Urrutia, Guillermo. Consejo Nacional de Investigaciones Científicas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina
dc.description.fil
Fil: Branham, Maria Teresita. Consejo Nacional de Investigaciones Científicas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina
dc.description.fil
Fil: Roque Moreno, Maria. Consejo Nacional de Investigaciones Científicas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina
dc.journal.title
Medical Epigenetics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.karger.com/Article/FullText/355616
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