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dc.contributor.author Di Pietro, Mariana
dc.contributor.author Parborell, Maria Fernanda Agustina
dc.contributor.author Irusta, Griselda
dc.contributor.author Pascuali, Natalia Marisa
dc.contributor.author Bas, Diana Ester
dc.contributor.author Bianchi, Maria Silvia
dc.contributor.author Tesone, Marta
dc.contributor.author Abramovich, Dalhia Nurit
dc.date.available 2016-12-27T15:48:48Z
dc.date.issued 2015-06-15
dc.identifier.citation Di Pietro, Mariana; Parborell, Maria Fernanda Agustina; Irusta, Griselda; Pascuali, Natalia Marisa; Bas, Diana Ester; et al.; Metformin regulates ovarian angiogenesis and follicular development in a female Polycystic Ovary Syndrome rat model; Endocrine Society; Endocrinology; 156; 4; 15-6-2015; 1453-1463
dc.identifier.issn 0013-7227
dc.identifier.uri http://hdl.handle.net/11336/10293
dc.description.abstract Polycystic ovary syndrome (PCOS) is a frequent pathology that affects more than 5% of women of reproductive age. Among other heterogeneous symptoms, PCOS is characterized by abnormalities in angiogenesis. Metformin has been introduced in the treatment of PCOS to manage insulin resistance and hyperglycemia. Besides its metabolic effects, metformin has been shown to improve ovulation, pregnancy and live birth rates in PCOS patients. In the present study, we used a dehydroepiandrosterone-induced PCOS rat model to analyze the effect of metformin administration on ovarian angiogenesis. We found that metformin was able to restore the increased levels of vascular endothelial growth factor, angiopoietin (ANGPT)1, and ANGPT1/ANGPT2 ratio and the decreased levels of platelet-derived growth factor B and platelet-derived growth factor D observed in the dehydroepiandrosterone-treated rats. These effects could take place, at least in part, through a decrease in the levels of serum insulin. We also found an improvement in follicular development, with a lower percentage of small follicles and cysts and a higher percentage of antral follicles and corpora lutea after metformin administration. The improvement in ovarian angiogenesis is likely to restore the accumulation of small follicles observed in PCOS rats and to reduce cyst formation, thus improving follicular development and the percentage of corpora lutea. These results open new insights into the study of metformin action not only in glucose metabolism but also in ovarian dysfunction in PCOS women
dc.format application/pdf
dc.language.iso eng
dc.publisher Endocrine Society
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject METFORMIN
dc.subject ANGIOGENESIS
dc.subject OVARY
dc.subject POLYCYSTIC OVARY SYNDROME
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Otras Medicina Básica
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Metformin regulates ovarian angiogenesis and follicular development in a female Polycystic Ovary Syndrome rat model
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-10-04T19:25:30Z
dc.identifier.eissn 1945-7170
dc.journal.volume 156
dc.journal.number 4
dc.journal.pagination 1453-1463
dc.journal.pais Estados Unidos
dc.journal.ciudad Los Angeles
dc.description.fil Fil: Di Pietro, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Pascuali, Natalia Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Bas, Diana Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Bianchi, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title Endocrinology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://press.endocrine.org/doi/abs/10.1210/en.2014-1765
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/en.2014-1765


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)