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dc.contributor.author
Azurmendi, Pablo Javier
dc.contributor.author
Fraga, Adriana Raquel
dc.contributor.author
Galan, Felicita M.
dc.contributor.author
Kotliar, Carol Virginia
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Arrizurieta, Elvira
dc.contributor.author
Valdez, Marta G.
dc.contributor.author
Forcada, Pedro
dc.contributor.author
Santelha Stefan, Jose S.
dc.contributor.author
Martin, Rodolfo Santiago
dc.date.available
2020-04-17T17:12:37Z
dc.date.issued
2009-12
dc.identifier.citation
Azurmendi, Pablo Javier; Fraga, Adriana Raquel; Galan, Felicita M.; Kotliar, Carol Virginia; Arrizurieta, Elvira; et al.; Early renal and vascular changes in ADPKD patients with low-grade; Oxford University Press; Nephrology Dialysis Transplantation; 24; 8; 12-2009; 2458-2463
dc.identifier.issn
0931-0509
dc.identifier.uri
http://hdl.handle.net/11336/102906
dc.description.abstract
Background. Autosomal dominant polycystic kidney dis- ease (ADPKD) shows an increase in both urine monocyte chemoattractant protein-1 (MCP-1) and carotid intima? media thickness (CIMT) before changes in serum creatinine concentration. Although microalbuminuria is an index of disease progression, data on whether renal alterations and vascular remodelling are already present at normal or minimally increased levels of urine albumin excretion in early stages of the disease are lacking. Methods. Forty-eight ADPKD patients (24.8 ± 0.8 years) with normal renal function (MDRD 108.1 ± 3.1 ml/min) and 21 age-matched controls were studied in a crosssectional study. The urine albumin/creatinine ratio (UACR) above the upper range of controls (6.8 mg/g) was taken as the predictor of renal alterations and vascular remodelling. Urine MCP-1, MCP-1 fractional excretion (FE ), endothelial-dependent vascular relaxation (EDVR), aortic pulse-wave velocity (Ao-PWV) and CIMT were chosen as biological markers. Results. No differences between ADPKD with UACR ≤ 6.8 mg/g and controls were observed in urine MCP-1 (77.7 ± 13.9 versus 57.8 ± 6.3 ng/g), FE (91 ± 19 versus 74 ± 8%) and CIMT (0.47 ± 0.06 versus 0.44 ± 0.07 mm), respectively. Conversely, ADPKD with UACR > 6.8 mg/g showed values that were different from the two other groups. In addition, patients with UACR > 6.8 and < 20 mg/g showed greater values for urine MCP-1, FE MCP-1 and CIMT (131.8 ± 21.7 ng/g, 159 ± 31% and 0.55 ± 0.05 mm, respectively), as compared with patients with UACR ≤ 6.8 mg/g. The same pattern was found in a subset of normotensive ADPKD patients. No differences were found in EDVR and Ao-PWV. Conclusion. In young ADPKD patients, normal levels of UACR suggest that renal interstitium is comparable to that in healthy subjects and indicate an absence of subtle atherosclerotic changes in the carotid arteries. Likewise, early renal and vascular changes may be present at UACR below the levels defined as microalbuminuria. MCP-1 MCP-1
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALBUMINURIA
dc.subject
AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
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CAROTIDA INTIMA MEDIA THICKNESS
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ENDOTELIAL DEPENDENT VASCULAR RELAXATION
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MONOCYTE CHEMOATRACTANT PROTEYNE
dc.subject.classification
Urología y Nefrología
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Early renal and vascular changes in ADPKD patients with low-grade
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-17T14:35:59Z
dc.journal.volume
24
dc.journal.number
8
dc.journal.pagination
2458-2463
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Fraga, Adriana Raquel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Galan, Felicita M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Kotliar, Carol Virginia. Universidad Austral. Hospital Universitario Austral. Areas de Responsabilidad.; Argentina
dc.description.fil
Fil: Arrizurieta, Elvira. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Valdez, Marta G.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Forcada, Pedro. Universidad Austral. Hospital Universitario Austral. Areas de Responsabilidad.; Argentina
dc.description.fil
Fil: Santelha Stefan, Jose S.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Martin, Rodolfo Santiago. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad Austral. Hospital Universitario Austral. Areas de Responsabilidad.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Nephrology Dialysis Transplantation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ndt/gfp136
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ndt/article/24/8/2458/1941307
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