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dc.contributor.author
Vicario, Jose
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Campo, Cesar
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Piva, Julio
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Faccio, Fernando
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Gerardo, Luis
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Becker, Carlos
dc.contributor.author
Ortega, Hugo Hector
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dc.contributor.author
Pierini, Angel
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Lofeudo, Carlos
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Novero, Rafael
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Baliño, Nestor Perez
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Monti, Adrian
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Benech, Rodolfo
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Dallo, Matias
dc.contributor.author
Pfeiffer, Hernan
dc.date.available
2020-04-17T11:58:33Z
dc.date.issued
2005-07
dc.identifier.citation
Vicario, Jose; Campo, Cesar; Piva, Julio; Faccio, Fernando; Gerardo, Luis; et al.; One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina; Elsevier; Cardiovascular Revascularization Medicine; 6; 3; 7-2005; 99-107
dc.identifier.issn
1553-8389
dc.identifier.uri
http://hdl.handle.net/11336/102845
dc.description.abstract
Purpose: Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-13T13:16:30Z
dc.journal.volume
6
dc.journal.number
3
dc.journal.pagination
99-107
dc.description.fil
Fil: Vicario, Jose. Hospital Iturraspe; Argentina
dc.description.fil
Fil: Campo, Cesar. Hospital Iturraspe; Argentina
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Fil: Piva, Julio. Hospital Iturraspe; Argentina
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Fil: Faccio, Fernando. Hospital San Gerónimo; Argentina
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Fil: Gerardo, Luis. Hospital Garay; Argentina
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Fil: Becker, Carlos. Hospital San Gerónimo; Argentina
dc.description.fil
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
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Fil: Pierini, Angel. Hospital Iturraspe; Argentina
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Fil: Lofeudo, Carlos. Hospital Garay; Argentina
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Fil: Novero, Rafael. Hospital Garay; Argentina
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Fil: Baliño, Nestor Perez. Hospital Santa Fe; Argentina
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Fil: Monti, Adrian. Hospital Garay; Argentina
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Fil: Benech, Rodolfo. Hospital Iturraspe; Argentina
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Fil: Dallo, Matias. Hospital Garay; Argentina
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Fil: Pfeiffer, Hernan. Hospital Iturraspe; Argentina
dc.journal.title
Cardiovascular Revascularization Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.carrev.2005.08.002
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