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dc.contributor.author
Cámara, María Silvia  
dc.contributor.author
Mastandrea, Carlos Raúl  
dc.contributor.author
Goicoechea, Hector Casimiro  
dc.date.available
2020-04-15T19:20:47Z  
dc.date.issued
2005-09  
dc.identifier.citation
Cámara, María Silvia; Mastandrea, Carlos Raúl; Goicoechea, Hector Casimiro; Chemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods; Elsevier Science; Journal Of Biochemical And Biophysical Methods; 64; 9-2005; 153-166  
dc.identifier.issn
0165-022X  
dc.identifier.uri
http://hdl.handle.net/11336/102674  
dc.description.abstract
In the present report, CBZ is determined on real patients samples by using a procedure completely assisted by chemometric tools. Firstly, a response surface methodology based on a mixture design was applied in order to select the best conditions in the extraction step. Finally, multivariate calibration PLS-1 was applied to second derivative UV spectra eliminating a shift baseline effect originated in the extraction procedure. The performance assessment included: a) a three level precision study, b) a recovery study analysing spiked samples, and c) method comparison with HPLC and FPIA methods applied on real patient samples. The results obtained show the potentiality of the presently studied methodology for the following of patients treated with this anticonvulsivant.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CARBAMAZEPINE  
dc.subject
SERUM SAMPLES  
dc.subject
CHEMOMETRICS  
dc.subject
PARTIAL LEAST SQUARES REGRESSION  
dc.subject.classification
Química Analítica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Chemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-04-13T13:13:51Z  
dc.journal.volume
64  
dc.journal.pagination
153-166  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Cámara, María Silvia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina  
dc.description.fil
Fil: Mastandrea, Carlos Raúl. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina  
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
dc.journal.title
Journal Of Biochemical And Biophysical Methods  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0165022X05001119  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jbbm.2005.07.001  

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