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dc.contributor.author
Almazán, Consuelo
dc.contributor.author
Blas Machado, Uriel
dc.contributor.author
Kocan, Katherine M.
dc.contributor.author
Yoshioka, Joy H.
dc.contributor.author
Blouin, Edmour F.
dc.contributor.author
Mangold, Atilio Jose
dc.contributor.author
de la Fuente, José
dc.date.available
2020-04-14T21:27:59Z
dc.date.issued
2005-08
dc.identifier.citation
Almazán, Consuelo; Blas Machado, Uriel; Kocan, Katherine M.; Yoshioka, Joy H.; Blouin, Edmour F.; et al.; Characterization of three Ixodes scapularis cDNAs protective against tick infestations; Elsevier; Vaccine; 23; 35; 8-2005; 4403-4416
dc.identifier.issn
0264-410X
dc.identifier.uri
http://hdl.handle.net/11336/102580
dc.description.abstract
cDNA expression library immunization (ELI) and analysis of expressed sequenced tags (EST) in a mouse model of tick infestations was used to identified cDNA clones that affected I. scapularis. Three protective antigens against larval tick infestations, 4F8, with homology to a nucleotidase, and 4D8 and 4E6 of unknown function, were selected for further characterization. All three antigens were expressed in all I. scapularis stages and localized in adult tick tissues. 4D8 was shown to be conserved in six other tick species. Based on immunization trials with synthetic polypeptides against larvae and nymphs and on artificial feeding experiments of adults, these antigens, especially 4D8, appear to be good candidates for continued development of a vaccine for control of tick infestations and may be useful in a formulation to target multiple species of ticks.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tick
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Recombinant protein
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EST
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Expression library immunization
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Vaccine
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Characterization of three Ixodes scapularis cDNAs protective against tick infestations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-13T13:16:58Z
dc.journal.volume
23
dc.journal.number
35
dc.journal.pagination
4403-4416
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Almazán, Consuelo. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Blas Machado, Uriel. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Yoshioka, Joy H.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Blouin, Edmour F.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Mangold, Atilio Jose. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: de la Fuente, José. Oklahoma State University; Estados Unidos. Universidad de Castilla-La Mancha. Instituto de Investigación en Recursos Cinegéticos; España. Consejo Superior de Investigaciones Científicas; España
dc.journal.title
Vaccine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vaccine.2005.04.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0264410X05004408
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