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dc.contributor.author
González, Germán Esteban  
dc.contributor.author
Rabald, Steffen  
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Briest, Wilfried  
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Gelpi, Ricardo Jorge  
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Seropian, Ignacio Miguel  
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Zimmer, Heinz Gerd  
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Deten, Alexander  
dc.date.available
2020-04-14T17:09:58Z  
dc.date.issued
2009-08  
dc.identifier.citation
González, Germán Esteban; Rabald, Steffen; Briest, Wilfried; Gelpi, Ricardo Jorge; Seropian, Ignacio Miguel; et al.; Ribose Treatment Reduced the Infarct Size and Improved Heart Function after Myocardial Infarction in Rats; Karger; Cellular Physiology and Biochemistry; 24; 3-4; 8-2009; 211-218  
dc.identifier.issn
1015-8987  
dc.identifier.uri
http://hdl.handle.net/11336/102484  
dc.description.abstract
Objective: In this study the effect of ribose on heart function and infarct-size was analyzed 6 h after myocardial infarction (MI) in rats. Methods: Continuous i.v.-infusion of NaCl or ribose (200 mg/ kg/h) was started one day prior to induction of MI in female Sprague-Dawley rats which was done by ligation of the left coronary artery. Six hours after MI heart function was measured with 3F tip catheter, cardiac output by thermodilution method. Thereafter the ischemic area was delineated by Evans Blue infusion, and the infarct area was visualized by triphenyltetrazolium chloride staining. The mRNA expression of interleukin (IL)-1β, IL-6, matrixmetalloproteinase (MMP)-8, and -9 was measured by ribonuclease protection assay. Results: Heart function was severely depressed 6 hours after coronary artery occlusion, but recovered significantly under the influence of ribose. Left ventricular (LV) systolic pressure (LVSP) and contractility (LVdP/dtmax) were restored to the normal levels of sham-operated animals, while parameters of LV relaxation (LVdP/dtmin and time constant of relaxation τ) were impaired compared to sham-operated animals, but significantly improved by ribose treatment compared to shamtreated MI-rats. Moreover, the infarct size was significantly smaller in the ribose treated animals despite a comparable ischemic area at risk in all MI-rats. The cytokine mRNA expression after MI was significantly reduced after ribose treatment, while there were no differences regarding MMP expression. Conclusion: MI size was significantly reduced and LV function significantly improved by ribose treatment at 6 h after MI. This seemed to be based on slowing the velocity of the necrotic wave front across the LV wall after MI resulting in smaller infarcts.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Karger  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
myocardial infarction  
dc.subject
ribose  
dc.subject.classification
Farmacología y Farmacia  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Ribose Treatment Reduced the Infarct Size and Improved Heart Function after Myocardial Infarction in Rats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-04-14T13:37:02Z  
dc.journal.volume
24  
dc.journal.number
3-4  
dc.journal.pagination
211-218  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basel  
dc.description.fil
Fil: González, Germán Esteban. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Rabald, Steffen. University of Leipzig; Alemania  
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Fil: Briest, Wilfried. University of Leipzig; Alemania  
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Fil: Gelpi, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina  
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Fil: Seropian, Ignacio Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina  
dc.description.fil
Fil: Zimmer, Heinz Gerd. University of Leipzig; Alemania  
dc.description.fil
Fil: Deten, Alexander. University of Leipzig; Alemania  
dc.journal.title
Cellular Physiology and Biochemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1159/000233247  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/233247