Artículo
Tick subolesin is an ortholog of the akirins described in insects and vertebrates
Galindo, Ruth C.; Doncel-Pérez, Ernesto; Zivkovic, Zorica; Naranjo, Victoria; Gortazar, Christian; Mangold, Atilio Jose
; Martín-Hernando, María Paz; Kocan, Katherine M.; Rodríguez de la Fuente, José Javier
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
04/2009
Editorial:
Elsevier
Revista:
Developmental And Comparative Immunology
ISSN:
0145-305X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host–pathogen interactions.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Citación
Galindo, Ruth C.; Doncel-Pérez, Ernesto; Zivkovic, Zorica; Naranjo, Victoria; Gortazar, Christian; et al.; Tick subolesin is an ortholog of the akirins described in insects and vertebrates; Elsevier; Developmental And Comparative Immunology; 33; 4; 4-2009; 612-617
Compartir
Altmétricas