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dc.contributor.author
Vargas Méndez, Leonor Y.
dc.contributor.author
Sanabria Flórez, Pedro L.
dc.contributor.author
Saavedra Reyes, Laura Marcela
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dc.contributor.author
Merchan Arenas, Diego R.
dc.contributor.author
Kouznetsov, Vladimir V.
dc.date.available
2020-04-07T20:56:51Z
dc.date.issued
2018-09
dc.identifier.citation
Vargas Méndez, Leonor Y.; Sanabria Flórez, Pedro L.; Saavedra Reyes, Laura Marcela; Merchan Arenas, Diego R.; Kouznetsov, Vladimir V.; Bioactivity of semisynthetic eugenol derivatives against Spodoptera frugiperda (Lepidoptera: Noctuidae) larvae infesting maize in Colombia; Elsevier; Saudi Journal of Biological Sciences; 26; 7; 9-2018; 1613-1620
dc.identifier.issn
1319-562X
dc.identifier.uri
http://hdl.handle.net/11336/102225
dc.description.abstract
The anti-acetylcholinesterase, larvicidal, antifeedant activities and general toxicity of 15 semisynthetic eugenol derivatives based on clove oil (including the own oil), were evaluated against the maize armyworm, Spodoptera frugiperda (J.E. Smith). Therefore, promising eugenol molecules were classified with larvicidal, anti-acetylcholinesterase and antifeedant activities for controlling this pest. During structure–activity relationship studies and physicochemical profile analysis, it was found that among tested molecules 1-15, eugenol 1, prenyl eugenol 4, isoeugenol 8 and isoeugenol acetate 11 exhibited lethal effects LD50 at concentrations < 1 mg/g of insect. On the other hand, eugenol 1, metallyl eugenol 3, isoeugenol 8 and isoeugenol acetate 11 showed a good antifeedant activity (CE50 =158-209 µg/mL) with a high antifeedant index (70-78 %) at concentration 1000 µg/mL, possessing a weak antiacetylcholinesterase activity (IC50 = 21-31 g/mL). According to their ecotoxicological profiles (LC50 = 2033.1-6303.8 µg/mL on Artemia salina larvae), isoeugenol 8 and its acetate derivative 11 could be potential used in control of the growth, feeding, or reproduction of S. frugiperda larvae, acting as moderate insecticidal acetylcholinesterase inhibitors and/or antifeedant molecules. Such structure–activity relationship studies could stimulate the identification of lead structures from natural sources for the development of larvicidal and deterrent products against S. frugiperda and related insect pests.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACETYLCHOLINESTERASE ACTIVITY
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ANTIFEEDANT ACTIVITY
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CLOVE OIL
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EUGENOL DERIVATIVES
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INSECTICIDAL ACTIVITY
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SPODOPTERA FRUGIPERDA
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TOXICITY ON ARTEMIA SALINA LARVAE
dc.subject.classification
Química Orgánica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Bioactivity of semisynthetic eugenol derivatives against Spodoptera frugiperda (Lepidoptera: Noctuidae) larvae infesting maize in Colombia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-02T15:15:21Z
dc.journal.volume
26
dc.journal.number
7
dc.journal.pagination
1613-1620
dc.journal.pais
Arabia Saudita
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dc.description.fil
Fil: Vargas Méndez, Leonor Y.. Universidad Santo Tomás; Colombia
dc.description.fil
Fil: Sanabria Flórez, Pedro L.. Universidad Santo Tomás; Colombia
dc.description.fil
Fil: Saavedra Reyes, Laura Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Santo Tomás; Colombia
dc.description.fil
Fil: Merchan Arenas, Diego R.. Universidad Industrial Santander; Colombia
dc.description.fil
Fil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; Colombia
dc.journal.title
Saudi Journal of Biological Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sjbs.2018.09.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1319562X18302262
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