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dc.contributor.author
Villena, Julio Cesar
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dc.contributor.author
Chiba, Eriko
dc.contributor.author
Vizoso Pinto, María Guadalupe
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dc.contributor.author
Tomosada, Yohsuke
dc.contributor.author
Takahashi, Takuya
dc.contributor.author
Ishizuka, Takuya
dc.contributor.author
Aso, Takuya
dc.contributor.author
Salva, Maria Susana
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dc.contributor.author
Alvarez, Gladis Susana
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dc.contributor.author
Kitazawa, Haruki
dc.date.available
2020-04-06T20:49:09Z
dc.date.issued
2014-06
dc.identifier.citation
Villena, Julio Cesar; Chiba, Eriko; Vizoso Pinto, María Guadalupe; Tomosada, Yohsuke; Takahashi, Takuya; et al.; Immunobiotic Lactobacillus rhamnosus strains differentially modulate antiviral immune response in intestinal epithelial and antigen presenting cells; BioMed Central; BMC Microbiology; 14; 126; 6-2014; 1-14
dc.identifier.issn
1471-2180
dc.identifier.uri
http://hdl.handle.net/11336/102106
dc.description.abstract
Background: previous findings suggested that Lactobacillus rhamnosus CRL1505 is able to increase resistance of children to intestinal viral infections. However, the intestinal cells, cytokines and receptors involved in the immunoregulatory effect of this probiotic strain have not been fully characterized. Objective: we aimed to gain insight into the mechanisms involved in the immunomodulatory effect of the CRL1505 strain and therefore evaluated in vitro the crosstalk between L. rhamnosus CRL1505, porcine intestinal epithelial cells (IECs) and antigen presenting cells (APCs) from swine Peyer?s patches in order to deepen our knowledge about the mechanisms, through which this strain may help preventing viral diarrhoea episodes. Results: L. rhamnosus CRL1505 was able to induce IFN?α and ?β in IECs and improve the production of type I IFNs in response to poly(I:C) challenge independently of Toll-like receptor (TLR)-2 or TLR9 signalling. In addition, the CRL1505 strain induced mRNA expression of IL-6 and TNF-α via TLR2 in IECs. Furthermore, the strain significantly increased surface molecules expression and cytokine production in intestinal APCs. The improved Th1 response induced by L. rhamnosus CRL1505 was triggered by TLR2 signalling and included augmented expression of MHC-II and co-stimulatory molecules and expression of IL-1β, IL-6, and IFN-γ in APCs. IL-10 was also significantly up-regulated by CRL1505 in APCs. Conclusions: it was recently reviewed the emergence of TLR agonists as new ways to transform antiviral treatments by introducing panviral therapeutics with less adverse effects than IFN therapies. The use of L. rhamnosus CRL1505 as modulator of innate immunity and inductor of antiviral type I IFNs, IFN-γ, and regulatory IL-10 clearly offers the potential to overcome this challenge.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LACTOBACILLUS RHAMNOSUS
dc.subject
POLY(I:C)
dc.subject
ANTIVIRAL IMMUNITY
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PIE CELLS
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INTESTINAL ANTIGEN PRESENTING CELLS
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TLR2
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Immunobiotic Lactobacillus rhamnosus strains differentially modulate antiviral immune response in intestinal epithelial and antigen presenting cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-02T14:59:31Z
dc.identifier.eissn
1471-2180
dc.journal.volume
14
dc.journal.number
126
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
dc.description.fil
Fil: Chiba, Eriko. Tohoku University; Japón
dc.description.fil
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Tomosada, Yohsuke. Tohoku University; Japón
dc.description.fil
Fil: Takahashi, Takuya. Tohoku University; Japón
dc.description.fil
Fil: Ishizuka, Takuya. Tohoku University; Japón
dc.description.fil
Fil: Aso, Takuya. Tohoku University; Japón
dc.description.fil
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.journal.title
BMC Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1471-2180-14-126
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-14-126
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