Artículo
Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease
Bortolanza, Mariza; Nascimento, Glauce C.; Socias, Sergio Benjamin
; Ploper, Diego
; Chehin, Rosana Nieves
; Raisman Vozari, Rita; del Bel Belluz Guimaraes, Elaine
Fecha de publicación:
08/2018
Editorial:
Springer Wien
Revista:
Journal of Neural Transmission. General Section
ISSN:
0300-9564
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The prevalence of Parkinson´s disease, which affects millions of people worldwide, is increasing due to the aging population. In addition to the classic motor symptoms caused by the death of dopaminergic neurons, Parkinson´s disease encompasses a wide range of nonmotor symptoms. Although novel disease-modifying medications that slow or stop Parkinson´s disease progression are being developed, drug repurposing, which is the use of existing drugs that have passed numerous toxicity and clinical safety tests for new indications, can be used to identify treatment compounds. This strategy has revealed that tetracyclines are promising candidates for the treatment of Parkinson´s disease. Tetracyclines, which are neuroprotective, inhibit proinflammatory molecule production, matrix metalloproteinase activity, mitochondrial dysfunction, protein misfolding/aggregation, and microglial activation. Two commonly used semisynthetic second-generation tetracycline derivatives, minocycline and doxycycline, exhibit effective neuroprotective activity in experimental models of neurodegenerative/ neuropsychiatric diseases and no substantial toxicity. Moreover, novel synthetic tetracyclines with different biological properties due to chemical tuning are now available. In this review, we discuss the multiple effects and clinical properties of tetracyclines and their potential use in Parkinson´s disease treatment. In addition, we examine the hypothesis that the anti-inflammatory activities of tetracyclines regulate inflammasome signaling. Based on their excellent safety profiles in humans from their use for over 50 years as antibiotics, we propose the repurposing of tetracyclines, a multitarget antibiotic, to treat Parkinson´s disease.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Bortolanza, Mariza; Nascimento, Glauce C.; Socias, Sergio Benjamin; Ploper, Diego; Chehin, Rosana Nieves; et al.; Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease; Springer Wien; Journal of Neural Transmission. General Section; 125; 10; 8-2018; 1403-1415
Compartir
Altmétricas