Artículo
Changes in mucins and matrix metalloproteases in the endometrium of early pregnant alpacas (Vicugna pacos)
Barraza, Daniela Estefanía
; Zampini, Renato
; Apichela, Silvana Andrea
; Pacheco, Joel I.; Argañaraz, Martin Eduardo
Fecha de publicación:
07/2018
Editorial:
Elsevier Gmbh, Urban & Fischer Verlag
Revista:
Acta Histochemica
ISSN:
0065-1281
e-ISSN:
1618-0372
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
South American Camelids (SAC) have unique reproductive features, one of which is that 98% of the pregnancies develop in the left uterine horn. Furthermore, early pregnancy is an uncharacterized process in these species, especially in regard to the ultrastructural, biochemical and genetic changes that the uterine epithelial surface undergoes to allow embryo implantation. The present study describes the uterine horn luminal surface and the characteristics of the mucinous glycocalyx in non-pregnant and early pregnant (15 days) female alpacas. In addition, the relative abundance of Mucin 1 and 16 genes (MUC1 and MUC16) was determined, as well as the relative mRNA abundance of matrix metalloproteinases (MMPs) that could be involved in MUC shedding during early pregnancy. Noticeable changes were detected in the uterine luminal epithelium and glycocalyx of pregnant alpacas in comparison to non-pregnant ones, as well as presence of MUCs and MMPs in the endometrial environment. The decrease in glycocalyx staining and in the relative abundance of MUC 1 and MUC 16 transcripts in pregnant females would allow embryo attachment to the luminal epithelium and its subsequent implantation, as has been described in other mammals. These results suggest a crucial role of MUC1 and MUC16 and a possible role of MMPs in successful embryo implantation and survival in alpacas.
Palabras clave:
MUCIN
,
METALLOPROTEASES
,
EARLY PREGNANCY
,
ALPACAS
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Licencia
Identificadores
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Barraza, Daniela Estefanía; Zampini, Renato; Apichela, Silvana Andrea; Pacheco, Joel I.; Argañaraz, Martin Eduardo; Changes in mucins and matrix metalloproteases in the endometrium of early pregnant alpacas (Vicugna pacos); Elsevier Gmbh, Urban & Fischer Verlag; Acta Histochemica; 120; 5; 7-2018; 438-445
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