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dc.contributor.author
Balschun, Detlef
dc.contributor.author
Randolf, Anke
dc.contributor.author
Pitossi, Fernando Juan
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dc.contributor.author
Schneider, Horst
dc.contributor.author
Del Rey, Adriana
dc.contributor.author
Besedovsky, Hugo O.
dc.date.available
2020-04-01T18:27:41Z
dc.date.issued
2003-05
dc.identifier.citation
Balschun, Detlef; Randolf, Anke; Pitossi, Fernando Juan; Schneider, Horst; Del Rey, Adriana; et al.; Hippocampal interleukin-1β gene expression during long-term potentiation decays with age; Blackwell Publishing; Annals of the New York Academy of Sciences; 992; 1; 5-2003; 1-8
dc.identifier.issn
0077-8923
dc.identifier.uri
http://hdl.handle.net/11336/101544
dc.description.abstract
Interleukin-1 is a cytokine that, apart from its contribution to immunoregulation, can affect neuroendocrine mechanisms and brain functions. We have previously shown that an increase in the endogenous production of IL-1 in the dentate gyrus during LTP is relevant for the maintenance of this process. We report here that in middle-aged rats (12 to 16 months old), enhancement of IL-1 gene expression is diminished compared to that in young animals. Furthermore, basal levels of IL-1 gene expression were slightly reduced in middle-aged rats. The reduced upregulation of IL-1 gene expression during LTP was not accompanied by overt impairment of potentiation, suggesting that either the level of the cytokine is still enough to maintain synaptic plasticity in the dentate gyrus or that compensatory, probably less efficient, mechanisms develop during aging.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CYTOKINES
dc.subject
GENE EXPRESSION
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HIPPOCAMPUS
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INTERLEUKIN-1 (II-1)
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LONG-TERM POTENTIATION
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Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Hippocampal interleukin-1β gene expression during long-term potentiation decays with age
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-13T13:37:15Z
dc.identifier.eissn
1749-6632
dc.journal.volume
992
dc.journal.number
1
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Balschun, Detlef. Leibniz Institute For Neurobiology; Alemania
dc.description.fil
Fil: Randolf, Anke. Philipps Universität Marburg; Alemania
dc.description.fil
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Schneider, Horst. Philipps Universität Marburg; Alemania
dc.description.fil
Fil: Del Rey, Adriana. Philipps Universität Marburg; Alemania
dc.description.fil
Fil: Besedovsky, Hugo O.. Philipps Universität Marburg; Alemania
dc.journal.title
Annals of the New York Academy of Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03132.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1749-6632.2003.tb03132.x
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