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dc.contributor.author
Díaz, María del Carmen
dc.contributor.author
González, Norma Viviana
dc.contributor.author
Gómez, Susana
dc.contributor.author
Quiroga, Miguel Angel
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Najle, Roberto
dc.contributor.author
Barbeito, Claudio Gustavo
dc.date.available
2020-04-01T16:19:16Z
dc.date.issued
2014-10
dc.identifier.citation
Díaz, María del Carmen; González, Norma Viviana; Gómez, Susana; Quiroga, Miguel Angel; Najle, Roberto; et al.; Effect of a Single Dose of Cadmium on Pregnant Wistar Rats and their Offspring; Wiley Blackwell Publishing, Inc; Reproduction in Domestic Animals; 49; 6; 10-2014; 1049-1056
dc.identifier.issn
0936-6768
dc.identifier.uri
http://hdl.handle.net/11336/101519
dc.description.abstract
Cadmium (Cd) is a well-known toxicant targeting many organs, among them placenta. This heavy metal also has embryonary and foetal toxicity. This study was undertaken to analyse the effect of a single Cd dose administered at 4, 7, 10 or 15 days of gestation on the offspring of pregnant rats sacrificed at 20 days of gestation. Cadmium chloride was administered subcutaneously at 10 mg/kg body weight to Wistar pregnant dams; control animals received a proportionate volume of sterile normal saline by the same route. Maternal uteri, livers, kidneys and lungs, and foetuses were examined at necropsy. Samples of maternal organs and whole foetuses were collected for histopathologic examination, determination of Cd levels and staining by the Alizarin red S technique. Results revealed a clear embryotoxic and a teratogenic effect of this heavy metal, the former as a significant increase in the number of resorptions, and the latter as significant decrease of the gestational sac weight, and the size and weight of foetuses of Cd-treated dams as well as induced malformations in skull bones, vertebrae and thoracic, and pelvian limbs. The deleterious effects found were similar to those previously reported for other animal models suggesting a high conservation of the pathogenic mechanisms of Cd. Additionally, many of the addressed aspects showed a slight dependence on the time of administration of the toxic that might be due to the accumulation of the metal in different organs, as we were able to demonstrate by the analysis of its concentration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Embryonary toxicity
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Foetal toxicity
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Cadmium
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Pregnant
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Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Effect of a Single Dose of Cadmium on Pregnant Wistar Rats and their Offspring
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-30T16:23:19Z
dc.journal.volume
49
dc.journal.number
6
dc.journal.pagination
1049-1056
dc.journal.pais
Suecia
dc.journal.ciudad
Linköping
dc.description.fil
Fil: Díaz, María del Carmen. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: González, Norma Viviana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Gómez, Susana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Quiroga, Miguel Angel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Najle, Roberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
Reproduction in Domestic Animals
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/rda.12439
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/rda.12439
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