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dc.contributor.author
Losavio, Adriana Silvia
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dc.contributor.author
Muchnik, Salomon
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dc.date.available
2020-03-30T17:59:08Z
dc.date.issued
2000-12
dc.identifier.citation
Losavio, Adriana Silvia; Muchnik, Salomon; Facilitation of spontaneous acetylcholine release induced by activation of cAMP in rat neuromuscular junctions; Pergamon-Elsevier Science Ltd; Life Sciences; 66; 26; 12-2000; 2543-2556
dc.identifier.issn
0024-3205
dc.identifier.uri
http://hdl.handle.net/11336/101401
dc.description.abstract
Regulation of neurotransmitter release is thought to involve modulation of therelease probability by protein phosphorylation. Activation of the CAMP-proteinkinase A (PKA) pathway has been shown to facilitate synaptic transmission inmammalian neuromuscular synapses, although the relevant phosphorylation targetsare mostly unknown. We found that the inhibitor of the phosphodiesteraseaminophylline (1 m.M AMIN), the membrane-permeable analog of CAMP, 8-Br-CAMP (5 mM) and, the diect adenylate cyclase activator, forskolin (20 PM),induced an increase of miniature end-plate potentials (MEPPs) frequency in ratneuromuscular junctions. We investigated the possible involvement of the voltagedependentcalcium channels (VDCC), since these proteins are known to bephosphorylated by PKA. But this possibility was ruled out, since the increase inMEPPs frequency was not attenuated by the VDCC blocker Cd” (100 pM) and itwas observed when AMIN was studied on hyperosmotic response, which isindependent of [Ca2’10 and of Ca2’ infhrx through the VDCC. The lack of action ofAMIN on MEPPs frequency when [Ca’+]i was diminished by exposing thepreparations to zero Ca2’-EGTA solution (isotonic condition) or when nerveterminals were loaded with a permeant Ca2’ chelator (BAPTA-AM) (hypertoniccondition), indicate that cAMPmediated presynaptic facilitation is a function ofnerve terminal Ca2” concentration We also found that AMIN exerted a comparableincrease in MEPPs f%equency in control and high K” (10 and 15 mM), suggesting asingle mechanism of action for spontaneous and K+-induced secretion.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Facilitation of spontaneous acetylcholine release induced by activation of cAMP in rat neuromuscular junctions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-02T17:44:00Z
dc.journal.volume
66
dc.journal.number
26
dc.journal.pagination
2543-2556
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Losavio, Adriana Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Muchnik, Salomon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Life Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0024320500005889?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0024-3205(00)00588-9
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