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Artículo

Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands

Perez Leiros, ClaudiaIcon ; Rosignoli, Florencia; Genaro, Ana MariaIcon ; Sales, María ElenaIcon ; Sterin, Leonor JosefinaIcon ; Borda, Enri SantiagoIcon
Fecha de publicación: 03/2000
Editorial: Elsevier
Revista: Journal Of The Autonomic Nervous System
ISSN: 0165-1838
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

Muscarinic receptors play an important role in secretory and vasodilator responses in rat salivary glands. Nitric oxide synthase (NOS) appears to be one of the multiple effectors coupled to muscarinic receptors in both submandibular and sublingual glands although some differences have been found depending on the gland studied. First, submandibular glands had a lower basal activity of nitric oxide synthase than sublingual glands and the concentration-response curve for carbachol was bell-shaped in the former but not in sublingual glands. Second, cGMP levels displayed a similar profile to that observed for NOS activity in both glands. Third, protein kinase C also coupled to muscarinic receptor activation in the glands might have a regulatory effect on nitric oxide production since its activity was higher in basal conditions in submandibular than sublingual glands and it also increased in the presence of the agonist at a concentration that inhibited NOS activity in submandibular glands. The effects appear to be partly related to the expression of a minor population of M1 receptors in submandibular glands absent in sublingual as determined in binding and signaling experiments with the muscarinic receptor antagonist pirenzepine.
Palabras clave: MUSCARINIC ACETYLCHOLINE RECEPTORS , NITRIC OXIDE SYNTHASE , PROTEIN KINASE C , SUBMANDIBULAR AND SUBLINGUAL GLANDS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/100940
DOI: http://dx.doi.org/10.1016/s0165-1838(99)00102-2
URL: https://www.sciencedirect.com/science/article/abs/pii/S0165183899001022
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Perez Leiros, Claudia; Rosignoli, Florencia; Genaro, Ana Maria; Sales, María Elena; Sterin, Leonor Josefina; et al.; Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands; Elsevier; Journal Of The Autonomic Nervous System; 79; 2-3; 3-2000; 99-107
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