Mostrar el registro sencillo del ítem

dc.contributor.author
Cieślak, Anna  
dc.contributor.author
Wauthoz, Nathalie  
dc.contributor.author
Nieto Orellana, Alejandro  
dc.contributor.author
Lautram, Nolwenn  
dc.contributor.author
Béjaud, Jérôme  
dc.contributor.author
Hureaux, José  
dc.contributor.author
Lafleur, Michel  
dc.contributor.author
Benoit, Jean-Pierre  
dc.contributor.author
Salomon, Claudio Javier  
dc.contributor.author
Bastiat, Guillaume  
dc.date.available
2020-03-25T18:31:48Z  
dc.date.issued
2017-06  
dc.identifier.citation
Cieślak, Anna; Wauthoz, Nathalie; Nieto Orellana, Alejandro; Lautram, Nolwenn; Béjaud, Jérôme; et al.; Stealth nanocarriers based sterosomes using PEG post-insertion process; Elsevier Science; European Journal Of Pharmaceutics And Biopharmaceutics; 115; 6-2017; 31-38  
dc.identifier.issn
0939-6411  
dc.identifier.uri
http://hdl.handle.net/11336/100753  
dc.description.abstract
Sterosomes (STEs), a new and promising non-phospholipidic liposome platform based on palmitic acid (PA) and cholesterol (Chol) mixtures, need to have polyethylene glycol (PEG) chains grafted to their surface in order to obtain long-circulating nanocarriers in the blood stream. A post-insertion method was chosen to achieve this modification. The post-insertion process of PEG-modified distearoylphosphoethanolamine (DSPE-PEG) was monitored using the zeta potential value of STEs. Various conditions including PEG chain length and the DSPE-PEG/PA-Chol ratio, were explored. Zeta potential of STEs changed from about −40 mV for non-modified STEs to values close to 0 mV by the end of the process, i.e. for PEG-modified STEs. The kinetics of DSPE-PEG insertion and the stability of the resulting PEG-modified STEs were not considerably influenced, within the investigated range, by changes in PEG chain lengths and in DSPE-PEG/PA-Chol proportion. The post-insertion of PEG chains reduced in vitro complement activation as well as in vitro macrophage uptake compared to the non-modified STEs. Moreover, longer blood circulation time in mice was established for PEG-modified STEs intravenously injected compared to non-modified STEs. These results establish that post-insertion process of PEG chains to STEs is a promising strategy for developing long-term circulating drug delivery nanocarriers.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BIODISTRIBUTION  
dc.subject
CH50 EXPERIMENT  
dc.subject
MACROPHAGE UPTAKE  
dc.subject
PEG  
dc.subject
STEROSOMES  
dc.subject.classification
Otras Nanotecnología  
dc.subject.classification
Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Stealth nanocarriers based sterosomes using PEG post-insertion process  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-25T13:27:23Z  
dc.journal.volume
115  
dc.journal.pagination
31-38  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Cieślak, Anna. University Of Angers; Francia  
dc.description.fil
Fil: Wauthoz, Nathalie. University Of Angers; Francia. Université Libre de Bruxelles; Bélgica  
dc.description.fil
Fil: Nieto Orellana, Alejandro. University Of Angers; Francia  
dc.description.fil
Fil: Lautram, Nolwenn. University Of Angers; Francia  
dc.description.fil
Fil: Béjaud, Jérôme. University Of Angers; Francia  
dc.description.fil
Fil: Hureaux, José. University Of Angers; Francia  
dc.description.fil
Fil: Lafleur, Michel. University of Montreal; Canadá  
dc.description.fil
Fil: Benoit, Jean-Pierre. University Of Angers; Francia  
dc.description.fil
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Bastiat, Guillaume. University Of Angers; Francia  
dc.journal.title
European Journal Of Pharmaceutics And Biopharmaceutics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0939641117301996  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ejpb.2017.02.008