Artículo
Metallated porphyrin-doped conjugated polymer nanoparticles for efficient photodynamic therapy of brain and colorectal tumor cells
Ibarra, Luis Exequiel
; Porcal, Gabriela Valeria
; Macor, Lorena Paola
; Ponzio, Rodrigo Andrés
; Spada, Ramiro Martín
; Lorente, Carolina
; Chesta, Carlos Alberto
; Rivarola, Viviana Alicia; Palacios, Rodrigo Emiliano
Fecha de publicación:
03/2018
Editorial:
Future Medicine
Revista:
Nanomedicine
ISSN:
1743-5889
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Assess biocompatibility, uptake and photodynamic therapy (PDT) mechanism of metallated porphyrin doped conjugated polymer nanoparticles (CPNs) in human brain and colorectal tumor cells and macrophages. CPNs were developed employing 9,9-dioctylfluorene-altbenzothiadiazole, an amphiphilic polymer (PS-PEG-COOH), and platinum octaethylporphyrin. T98G, SW480 and RAW 264.7 cell lines were exposed to CPNs to assess uptake and intracellular localization. Additionally, a PDT protocol using CPNs was employed for the in vitro killing of cancer and macrophage cell lines. CPNs were well incorporated into glioblastoma and macrophage cells with localization in lysosomes. SW480 cells were less efficient incorporating CPNswith localization in the plasma membrane. In all cell lines PDT treatment was efficient inducing oxidative stress that triggered apoptosis.
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Ibarra, Luis Exequiel; Porcal, Gabriela Valeria; Macor, Lorena Paola; Ponzio, Rodrigo Andrés; Spada, Ramiro Martín; et al.; Metallated porphyrin-doped conjugated polymer nanoparticles for efficient photodynamic therapy of brain and colorectal tumor cells; Future Medicine; Nanomedicine; 13; 6; 3-2018; 605-624
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