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dc.contributor.author
Thomas, Nancy E.
dc.contributor.author
Kricker, Anne
dc.contributor.author
From, Lynn
dc.contributor.author
Busam, Klaus
dc.contributor.author
Millikan, Robert C.
dc.contributor.author
Ritchey, Mary E.
dc.contributor.author
Armstrong, Bruce K.
dc.contributor.author
Lee-Taylor, Julia
dc.contributor.author
Marrett, Loraine D.
dc.contributor.author
Anton Culver, Hoda
dc.contributor.author
Zanetti, Roberto
dc.contributor.author
Rosso, Stefano
dc.contributor.author
Gallagher, Richard P.
dc.contributor.author
Dwyer, Terence
dc.contributor.author
Goumas, Chris
dc.contributor.author
Kanetsky, Peter A.
dc.contributor.author
Begg, Colin B.
dc.contributor.author
Orlow, Irene
dc.contributor.author
Wilcox, Homer
dc.contributor.author
Paine, Susan
dc.contributor.author
Berwick, Marianne
dc.contributor.author
Mujumdar, Urvi
dc.contributor.author
Hummer, Amanda J.
dc.contributor.author
Mitra, Nandita
dc.contributor.author
Roy, Pampa
dc.contributor.author
Canchola, Rebecca
dc.contributor.author
Clas, Brian
dc.contributor.author
Cotignola, Javier Hernan
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dc.contributor.author
Monroe, Yvette
dc.contributor.author
Litchfield, Melisa
dc.contributor.author
Tucker, Paul
dc.contributor.author
Stephens, Nicola
dc.contributor.author
Switzer, Teresa
dc.contributor.author
Theis, Elizabeth
dc.contributor.author
Chowdhury, Noori
dc.contributor.author
Vanasse, Louise
dc.contributor.author
Purdue, Mark
dc.contributor.author
Northrup, David
dc.contributor.author
Sacerdote, Carlotta
dc.contributor.author
Leighton, Nancy
dc.contributor.author
Gildea, Maureen
dc.contributor.author
Gruber, Stephen B.
dc.contributor.author
Bonner, Joe
dc.contributor.author
Jeter, Joanne
dc.contributor.author
Klotz, Judith
dc.contributor.author
Weiss, Helen
dc.contributor.author
Mattingly, Dianne
dc.contributor.author
Player, Jon
dc.contributor.author
Tse, Chiu-Kit
dc.contributor.author
Rebbeck, Timothy R.
dc.contributor.author
Kanetsky, Peter
dc.contributor.author
Walker, Amy
dc.contributor.author
Panossian, Saarene
dc.contributor.author
Mohrenweiser, Harvey
dc.contributor.author
Setlow, Richard
dc.contributor.author
Taylor, Julia Lee
dc.contributor.author
Madronich, Sasha
dc.date.available
2020-03-19T19:09:26Z
dc.date.issued
2010-11
dc.identifier.citation
Thomas, Nancy E.; Kricker, Anne; From, Lynn; Busam, Klaus; Millikan, Robert C.; et al.; Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis; American Association for Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; 19; 11; 11-2010; 2932-2941
dc.identifier.issn
1055-9965
dc.identifier.uri
http://hdl.handle.net/11336/100342
dc.description.abstract
Background: Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored. Methods: The study included 2,589 incident primary melanoma patients with assessment of histologic solar elastosis in the population-based Genes, Environment, and Melanoma study. Ambient erythemal UV (UVE) at places of residence and sun exposure hours, including body site-specific exposure, were collected. We examined the association of cumulative site-specific and non-site-specific sun exposure hours and ambient UVE with solar elastosis in multivariable models adjusted for age, sex, center, pigmentary characteristics, nevi, and, where relevant, body site. Results: Solar elastosis was associated most strongly with site-specific UVE [odds ratio (OR) for top exposure quartile, 5.20; 95% confidence interval (95% CI), 3.40-7.96; P for trend <0.001] and also with site-specific sun exposure (OR for top quartile, 5.12; 95% CI, 3.35-7.83; P for trend <0.001). Older age (OR at >70 years, 7.69; 95% CI, 5.14-11.52; P for trend < 0.001) and having more than 10 back nevi (OR, 0.77; 95% CI, 0.61-0.97; P = 0.03) were independently associated with solar elastosis. Conclusion: Solar elastosis had a strong association with higher site-specific UVE dose, older age, and fewer nevi. Impact: Solar elastosis could be a useful biomarker of lifetime site-specific UV. Future research is needed to explore whether age represents more than simple accumulation of sun exposure and to determine why people with more nevi may be less prone to solar elastosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association for Cancer Research
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melanoma
dc.subject
Solar Elastosis
dc.subject
Phenotype
dc.subject
Uv Exposure
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-22T15:28:20Z
dc.journal.volume
19
dc.journal.number
11
dc.journal.pagination
2932-2941
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Thomas, Nancy E..
dc.description.fil
Fil: Kricker, Anne.
dc.description.fil
Fil: From, Lynn.
dc.description.fil
Fil: Busam, Klaus.
dc.description.fil
Fil: Millikan, Robert C..
dc.description.fil
Fil: Ritchey, Mary E..
dc.description.fil
Fil: Armstrong, Bruce K..
dc.description.fil
Fil: Lee-Taylor, Julia.
dc.description.fil
Fil: Marrett, Loraine D..
dc.description.fil
Fil: Anton-Culver, Hoda.
dc.description.fil
Fil: Zanetti, Roberto.
dc.description.fil
Fil: Rosso, Stefano.
dc.description.fil
Fil: Gallagher, Richard P..
dc.description.fil
Fil: Dwyer, Terence.
dc.description.fil
Fil: Goumas, Chris.
dc.description.fil
Fil: Kanetsky, Peter A..
dc.description.fil
Fil: Begg, Colin B..
dc.description.fil
Fil: Orlow, Irene.
dc.description.fil
Fil: Wilcox, Homer.
dc.description.fil
Fil: Paine, Susan.
dc.description.fil
Fil: Berwick, Marianne.
dc.description.fil
Fil: Mujumdar, Urvi.
dc.description.fil
Fil: Hummer, Amanda J..
dc.description.fil
Fil: Mitra, Nandita.
dc.description.fil
Fil: Roy, Pampa.
dc.description.fil
Fil: Canchola, Rebecca.
dc.description.fil
Fil: Clas, Brian.
dc.description.fil
Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Monroe, Yvette.
dc.description.fil
Fil: Litchfield, Melisa.
dc.description.fil
Fil: Tucker, Paul.
dc.description.fil
Fil: Stephens, Nicola.
dc.description.fil
Fil: Switzer, Teresa.
dc.description.fil
Fil: Theis, Elizabeth.
dc.description.fil
Fil: Chowdhury, Noori.
dc.description.fil
Fil: Vanasse, Louise.
dc.description.fil
Fil: Purdue, Mark.
dc.description.fil
Fil: Northrup, David.
dc.description.fil
Fil: Sacerdote, Carlotta.
dc.description.fil
Fil: Leighton, Nancy.
dc.description.fil
Fil: Gildea, Maureen.
dc.description.fil
Fil: Gruber, Stephen B..
dc.description.fil
Fil: Bonner, Joe.
dc.description.fil
Fil: Jeter, Joanne.
dc.description.fil
Fil: Klotz, Judith.
dc.description.fil
Fil: Weiss, Helen.
dc.description.fil
Fil: Mattingly, Dianne.
dc.description.fil
Fil: Player, Jon.
dc.description.fil
Fil: Tse, Chiu-Kit.
dc.description.fil
Fil: Rebbeck, Timothy R..
dc.description.fil
Fil: Kanetsky, Peter.
dc.description.fil
Fil: Walker, Amy.
dc.description.fil
Fil: Panossian, Saarene.
dc.description.fil
Fil: Mohrenweiser, Harvey.
dc.description.fil
Fil: Setlow, Richard.
dc.description.fil
Fil: Taylor, Julia Lee.
dc.description.fil
Fil: Madronich, Sasha.
dc.journal.title
Cancer Epidemiology, Biomarkers & Prevention
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://cebp.aacrjournals.org/content/19/11/2932
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1158/1055-9965.EPI-10-0686
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976811/
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