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dc.contributor.author
Haldar, Arun K.
dc.contributor.author
Saka, Hector Alex
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dc.contributor.author
Piro, Anthony S.
dc.contributor.author
Dunn, Joe Dan
dc.contributor.author
Henry, Stanley C.
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Taylor, Gregory A.
dc.contributor.author
Frickel, Eva M.
dc.contributor.author
Valdivia, Raphael H.
dc.contributor.author
Coers, Jörn
dc.date.available
2016-12-22T21:54:58Z
dc.date.issued
2013-06
dc.identifier.citation
Haldar, Arun K.; Saka, Hector Alex; Piro, Anthony S.; Dunn, Joe Dan; Henry, Stanley C.; et al.; IRG and GBP host resistance factors target aberrant, ‘‘Non-self’’ vacuoles characterized by the missing of ‘‘Self’’ IRGM proteins; Public Library Of Science; Plos Pathogens; 9; 6; 6-2013; 1-5
dc.identifier.issn
1553-7366
dc.identifier.uri
http://hdl.handle.net/11336/10015
dc.description.abstract
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic microbes. IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit immune pathways directed at the targeted vacuoles. Targeting of Interferon-inducible GTPases to PVs requires the formation of higher-order protein oligomers, a process negatively regulated by a subclass of IRG proteins called IRGMs. We found that the paralogous IRGM proteins Irgm1 and Irgm3 fail to robustly associate with ‘‘non-self’’ PVs containing either the bacterial pathogen Chlamydia trachomatis or the protozoan pathogen Toxoplasma gondii. Instead, Irgm1 and Irgm3 reside on ‘‘self’’ organelles including lipid droplets (LDs). Whereas IRGM-positive LDs are guarded against the stable association with other IRGs and GBPs, we demonstrate that IRGM-stripped LDs become high affinity binding substrates for IRG and GBP proteins. These data reveal that intracellular immune recognition of organelle-like structures by IRG and GBP proteins is partly dictated by the missing of ‘‘self’’ IRGM proteins from these structures.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Irg
dc.subject
Gbp
dc.subject
Droplets
dc.subject
Chlamydia
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
IRG and GBP host resistance factors target aberrant, ‘‘Non-self’’ vacuoles characterized by the missing of ‘‘Self’’ IRGM proteins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-19T18:05:16Z
dc.journal.volume
9
dc.journal.number
6
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Haldar, Arun K.. University Of Duke; Estados Unidos
dc.description.fil
Fil: Saka, Hector Alex. University Of Duke; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Piro, Anthony S.. University Of Duke; Estados Unidos
dc.description.fil
Fil: Dunn, Joe Dan. University Of Duke; Estados Unidos
dc.description.fil
Fil: Henry, Stanley C.. University Of Duke; Estados Unidos. Veteran Affairs Medical Center; Estados Unidos
dc.description.fil
Fil: Taylor, Gregory A.. University Of Duke; Estados Unidos. Veteran Affairs Medical Center; Estados Unidos
dc.description.fil
Fil: Frickel, Eva M.. National Institute for Medical Research; Reino Unido
dc.description.fil
Fil: Valdivia, Raphael H.. University Of Duke; Estados Unidos
dc.description.fil
Fil: Coers, Jörn. University Of Duke; Estados Unidos
dc.journal.title
Plos Pathogens
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003414
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.ppat.1003414
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681737/
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