Artículo
Immunological status of isolated lymphoid follicles after intestinal transplantation
Meier, Dominik; Docena, Guillermo H.
; Ramisch, D.; Toscanini, U.; Berardi, G.; Gondolesi, Gabriel Eduardo
; Rumbo, Martín
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Fecha de publicación:
09/2014
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
American Journal of Transplantation
ISSN:
1600-6135
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Intestinal transplantation (ITx) faces the challenge of grafting a high immunogenic organ, which is certainly one of the major obstacles for intestinal allograft acceptance. The allograft has to guarantee the proper functioning of the mucosal immune machinery under immunosuppressive conditions. Recently, it has been elucidated that isolated lymphoid follicles (ILFs) are an indispensable part of mucosal immunity to maintain IgA synthesis and consequently to control commensal microflora. No data about these follicular structures in the setting of ITx are available so far. Therefore, we addressed the question whether constitution, integrity and function of allograft ILFs are disturbed by immunosuppressive regimen. We compared allograft ILFs from terminal ileum of transplant patients with ILFs from nontransplant patients via flow cytometry, quantitative real-time polymerase chain reaction and immunohistochemistry. We found that host leukocytes rapidly repopulate allograft ILFs and that maintenance immunosuppressive regimen, tacrolimus and corticosteroids, does not affect their cellular integrity and function. However, allograft ILFs revealed a higher maturation state than control samples and IgA positive plasma cells were increased in number in allograft mucosa. Our results open the path for a better understanding of allograft mucosal immunity. This study shows that cellular integrity and function of isolated lymphoid follicles in the small bowel of transplanted patients are not affected by the immunosuppressive regimen, and that these lymphoid structures serve to better understand the mucosal immunity of the intestinal allograft.
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Identificadores
Colecciones
Articulos(IIFP)
Articulos de INST. DE ESTUDIOS INMUNOLOGICOS Y FISIOPATOLOGICOS
Articulos de INST. DE ESTUDIOS INMUNOLOGICOS Y FISIOPATOLOGICOS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Meier, Dominik; Docena, Guillermo H.; Ramisch, D.; Toscanini, U.; Berardi, G.; et al.; Immunological status of isolated lymphoid follicles after intestinal transplantation; Wiley Blackwell Publishing, Inc; American Journal of Transplantation; 14; 9; 9-2014; 2148-2158
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