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dc.contributor.author
Vargas, Annie Y.
dc.contributor.author
Rojas, Hugo A.
dc.contributor.author
Romanelli, Gustavo Pablo
dc.contributor.author
Martínez, José J.
dc.date.available
2018-03-06T18:12:34Z
dc.date.issued
2017-08
dc.identifier.citation
Vargas, Annie Y.; Rojas, Hugo A.; Romanelli, Gustavo Pablo; Martínez, José J.; Synthesis of 1,4-dihydropyrimidines with immobilized urease: Effect of method immobilization on magnetic supports; De Gruyter; Green Processing and Synthesis; 6; 4; 8-2017; 377-384
dc.identifier.issn
2191-9550
dc.identifier.uri
http://hdl.handle.net/11336/37970
dc.description.abstract
The effect of the urease immobilization method was studied on magnetic supports for the Biginelli/Hantzsch reaction. For this purpose, Fe3O4/SiO2 was modified with 3-Aminopropyl-Triethoxysilane and then activated with glutaraldehyde. A ratio of 500 mg of enzyme per gram of support at 4°C and 18 h were sufficient for the physical adsorption, while 24 h were required for covalent bonding. The Biginelli and Hantzsch reactions were used to evaluate urease application in multicomponent reactions (MCRs). The synthesis of 1,4-dihydropyrimidines was successfully performed using immobilized urease favoring the Hantzsch product. The magnetic properties of the supports allow easy separation, and the urease immobilized by both methods improved the enzymatic activity compared to that of free urease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
De Gruyter
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Biginelli/Hantzsch Reaction
dc.subject
Magnetic Supports
dc.subject
Urease Immobilized
dc.subject.classification
Otras Ingeniería Química
dc.subject.classification
Ingeniería Química
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Synthesis of 1,4-dihydropyrimidines with immobilized urease: Effect of method immobilization on magnetic supports
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-19T16:58:40Z
dc.journal.volume
6
dc.journal.number
4
dc.journal.pagination
377-384
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Vargas, Annie Y.. Universidad Pedagógica y Tecnológica de Colombia; Colombia
dc.description.fil
Fil: Rojas, Hugo A.. Universidad Pedagógica y Tecnológica de Colombia; Colombia
dc.description.fil
Fil: Romanelli, Gustavo Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas ; Argentina
dc.description.fil
Fil: Martínez, José J.. Universidad Pedagógica y Tecnológica de Colombia; Colombia
dc.journal.title
Green Processing and Synthesis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/gps-2016-0143
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/gps.2017.6.issue-4/gps-2016-0143/gps-2016-0143.xml
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