Artículo
Synthesis of 1,4-dihydropyrimidines with immobilized urease: Effect of method immobilization on magnetic supports
Fecha de publicación:
08/2017
Editorial:
De Gruyter
Revista:
Green Processing and Synthesis
ISSN:
2191-9550
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The effect of the urease immobilization method was studied on magnetic supports for the Biginelli/Hantzsch reaction. For this purpose, Fe3O4/SiO2 was modified with 3-Aminopropyl-Triethoxysilane and then activated with glutaraldehyde. A ratio of 500 mg of enzyme per gram of support at 4°C and 18 h were sufficient for the physical adsorption, while 24 h were required for covalent bonding. The Biginelli and Hantzsch reactions were used to evaluate urease application in multicomponent reactions (MCRs). The synthesis of 1,4-dihydropyrimidines was successfully performed using immobilized urease favoring the Hantzsch product. The magnetic properties of the supports allow easy separation, and the urease immobilized by both methods improved the enzymatic activity compared to that of free urease.
Palabras clave:
Biginelli/Hantzsch Reaction
,
Magnetic Supports
,
Urease Immobilized
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CINDECA)
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Citación
Vargas, Annie Y.; Rojas, Hugo A.; Romanelli, Gustavo Pablo; Martínez, José J.; Synthesis of 1,4-dihydropyrimidines with immobilized urease: Effect of method immobilization on magnetic supports; De Gruyter; Green Processing and Synthesis; 6; 4; 8-2017; 377-384
Compartir
Altmétricas