Artículo
Global chain properties of an all L-alpha-eicosapeptide with a secondary alpha -helix and its all retro D-inverso-alpha-eicosapeptide estimated through the modeling of their CZE determined electrophoretic mobilities
Fecha de publicación:
03/2014
Editorial:
Wiley
Revista:
Electrophoresis
ISSN:
0173-0835
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Several global chain properties of relatively long peptides composed of 20 amino acid residues are estimated through the modeling of their experimental effective electrophoretic mobilities determined by CZE for 2 < pH < 6. In this regard, an all L-alpha-eicosapeptide, including a secondary alpha-helix (Peptide 1) and its all retro D-inverso-alpha-eicosapeptide (Peptide 2), are considered. Despite Peptides 1 and 2 are isomeric chains, they do not present similar global conformations in the whole range of pH studied. These peptides may also differ in the quality of BGE components chain interactions depending on the pH value. Three Peptide 1 fragments (Peptides 3, 4, and 5) are also analyzed in this framework with the following purposes: (i) visualization of the effects of initial and final strands at each side of the alpha-helix on the global chain conformations of Peptide 1 at different pHs and (ii) analysis of global chain conformations of Peptides 1 and 2, and Peptide 1 fragments in relation to their pI values. Also, the peptidemaximum andminimum hydrations predicted by the model, compatible with experimental effective electrophoretic mobilities at different pHs, are quantified and discussed, and needs for further research concerning chain hydration are proposed. It is shown that CZE is a useful analytical tool for peptidomimetic designs and purposes.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Deiber, Julio Alcides; Piaggio, María Virginia; Peirotti, Marta Beatriz; Global chain properties of an all L-alpha-eicosapeptide with a secondary alpha -helix and its all retro D-inverso-alpha-eicosapeptide estimated through the modeling of their CZE determined electrophoretic mobilities; Wiley; Electrophoresis; 35; 5; 3-2014; 755-761
Compartir
Altmétricas
Items relacionados
Mostrando titulos relacionados por título, autor y tema.
-
Gutiérrez, Alicia Beatriz ; Sambuco, Lorena Andrea ; Alvarez, Laura; Núñez, Mariel Alejandra; Bergoc, Rosa Maria ; Zotta, Elsa; Martín, Gabriela; Randi, Andrea Silvana (Pergamon-Elsevier Science Ltd, 2020-01)
-
Artículo Enzymes required for maltodextrin catabolism in Enterococcus faecalis exhibit novel activitiesJoyet, Philippe; Mokhtari, Abdelhamid; Riboulet-Bisson, Eliette; Blancato, Victor Sebastian ; Espariz, Martin ; Magni, Christian ; Hartke, Axel; Deutscher, Josef; Sauvageot, Nicolas (American Society for Microbiology, 2017-07)
-
Wilcox, Kevin R.; Tredennick, Andrew T.; Koerner, Sally E.; Grman, Emily; Hallett, Lauren M.; Avolio, Meghan L.; La Pierre, Kimberly J.; Houseman, Gregory R.; Forest, Isbell; Johnson, David Samuel; Alatalo, Juha M.; Baldwin, Andrew H.; Bork, Edward W.; Boughton, Elizabeth H.; Bowman, William D.; Britton, Andrea J.; Cahill, James F.; Collins, Scott L.; Du, Guozhen; Eskelinen, Anu; Gough, Laura; Jentsch, Anke; Kern, Christel; Klanderud, Kari; Knapp, Alan K.; Kreyling, Juergen; Luo, Yiqi; McLaren, James E.; Megonigal, Patrick; Onipchenko, Vladimir; Prevéy, Janet; Price, Jodi N.; Robinson, Clare H.; Sala, Osvaldo Esteban ; Smith, Melinda D.; Soudzilovskaia, Nadejda A.; Souza, Lara; Tilman, David; White, Shannon R.; Xu, Zhuwen; Yahdjian, María Laura ; Yu, Qiang; Zhang, Pengfei; Zhang, Yunhai (Wiley Blackwell Publishing, Inc, 2017-12)