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dc.contributor.author
Ambrosi, Nella Gabriela
dc.contributor.author
Arrosagaray, Victoria
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Guerrieri, Diego
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Uva, Pablo Daniel
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Petroni, Jorgelina
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Buonpensiere, Mónica
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Iovanna, Juan Lucio
dc.contributor.author
León, Luis
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Incardona, Claudio
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Chuluyan, Hector Eduardo
dc.contributor.author
Casadei, Domingo
dc.date.available
2019-11-28T19:31:48Z
dc.date.issued
2016-04
dc.identifier.citation
Ambrosi, Nella Gabriela; Arrosagaray, Victoria; Guerrieri, Diego; Uva, Pablo Daniel; Petroni, Jorgelina; et al.; α-lipoic acid protects against ischemia-reperfusion injury in simultaneous kidney-pancreas transplantation; Lippincott Williams; Transplantation; 100; 4; 4-2016; 908-915
dc.identifier.issn
0041-1337
dc.identifier.uri
http://hdl.handle.net/11336/90815
dc.description.abstract
Background. Multiple factors have been implicated in the process of ischemia-reperfusion injury (IRI) in organ transplantation. Among these factors, oxidative damage seems to initiate the injury. á-lipoic acid (ALA) is a potent antioxidant that is used in patients with diabetic polyneuropathy. The aimof the present study was to determine the effect of ALA in patients undergoing simultaneous kidney-pancreas transplant by evaluating the functional recovery of the graft and biochemical markers of IRI.Methods. Twentysix patients were included in the following groups: (i) untreated control; (ii) donor and recipient (DR) ALA-treated, in which ALA was administered both to the deceased donor and to the recipients; and (iii) recipient ALA-treated group. The expression of inflammatory genes, as observed in biopsies taken at the end of surgery, as well as the serum cytokines, secretory leukocyte protease inhibitor, regenerating islet-derived protein 3â/pancreatitis-associated protein, amylase, lipase, glucose, and creatinine levels were quantified as markers of organ function. Results. The DR group showed high levels of TGFâ and low levels of C3 and TNFá in the kidneys, whereas high levels of C3 and heme oxygenase were identified in pancreas biopsies. Decreases in serum IL-8, IL-6, secretory leukocyte protease inhibitor, and regenerating islet-derived protein 3 â/pancreatitis-associated protein were observed after surgery in the DR group. Serum lipase and amylase were lower in the DR group than in the control and recipient groups. Early kidney dysfunction and clinical pancreatitis were higher in the control group than in either treatment group.Conclusions. These results show that ALA preconditioning is capable of reducing inflammatory markers while decreasing early kidney dysfunction and clinical posttransplant pancreatitis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
lipoic acid
dc.subject
ischemia reperfusion injury
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pancreas transplantation
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
α-lipoic acid protects against ischemia-reperfusion injury in simultaneous kidney-pancreas transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-21T17:36:24Z
dc.journal.volume
100
dc.journal.number
4
dc.journal.pagination
908-915
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Ambrosi, Nella Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
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Fil: Arrosagaray, Victoria. Instituto de Nefrología de Buenos Aires; Argentina
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Fil: Guerrieri, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Uva, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Nefrología de Buenos Aires; Argentina
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Fil: Petroni, Jorgelina. Instituto de Nefrología de Buenos Aires; Argentina
dc.description.fil
Fil: Buonpensiere, Mónica. Instituto de Nefrología de Buenos Aires; Argentina
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Fil: Iovanna, Juan Lucio. Aix-Marseille Université; Francia
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Fil: León, Luis. Instituto de Nefrología de Buenos Aires; Argentina
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Fil: Incardona, Claudio. Instituto de Nefrología de Buenos Aires; Argentina
dc.description.fil
Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Casadei, Domingo. Instituto de Nefrología de Buenos Aires; Argentina
dc.journal.title
Transplantation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00007890-201604000-00034
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/TP.0000000000000981
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