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dc.contributor.author
Casciato, Paola
dc.contributor.author
Ambrosi, Nella Gabriela
dc.contributor.author
Caro, Fiorella Yanina
dc.contributor.author
Vazquez, Mónica
dc.contributor.author
Müllen, Eduardo
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Gadano, Adrián Carlos
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de Santibanes, Eduardo
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de Santibañes, Martin
dc.contributor.author
Zandomeni, Marcos
dc.contributor.author
Chahdi, Magali
dc.contributor.author
Lazarte, Julio C.
dc.contributor.author
Biagiola, David A.
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Iaquinandi, Juan Cruz
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Santofimia-Castaño, Patricia
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Iovanna, Juan Lucio
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Incardona, Claudio
dc.contributor.author
Chuluyan, Hector Eduardo
dc.date.available
2019-11-25T20:48:16Z
dc.date.issued
2018-12
dc.identifier.citation
Casciato, Paola; Ambrosi, Nella Gabriela; Caro, Fiorella Yanina; Vazquez, Mónica; Müllen, Eduardo; et al.; α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study; Wiley Blackwell Publishing, Inc; Transplant International; 31; 12; 12-2018; 1357-1368
dc.identifier.issn
0934-0874
dc.identifier.uri
http://hdl.handle.net/11336/89751
dc.description.abstract
A double-blind randomized controlled trial was performed to compare the safety and efficacy of α-lipoic acid (ALA) in liver transplantation (LT). The grafts were randomized to receive ALA or placebo before the cold ischemia time. Furthermore, patients transplanted with the ALA-perfused graft received 600 mg of intravenous ALA, while patients with the nonperfused graft received the placebo just before graft reperfusion. Hepatic biopsy was performed 2 h postreperfusion. Blood samples were collected before, during and 1 and 2 days after reperfusion. Quantitative polymerase chain reaction (qPCR) analysis was performed on biopsies to assess genes involved in the response to hypoxia, apoptosis, cell growth, survival and proliferation, cytokine production and tissue damage protection. Nine of 40 patients developed postreperfusion syndrome (PRS), but seven of them belonged to the control group. There was a decrease in PHD2 and an increase in alpha subunit of hypoxia-inducible factor-1 (HIF-1α) and baculoviral IAP repeat containing 2 (Birc2) transcript levels in the biopsies from the ALA-treated versus the control group of patients. Additionally, plasma levels of alarmins were lower in ALA-treated patients than control patients, which suggests that ALA-treated grafts are less inflammatory than untreated grafts. These results showed that ALA is safe for use in LT, induces gene changes that protect against hypoxia and oxidative stress and reduces the appearance of PRS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALPHA LIPOIC ACID
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ISCHEMIA REPERFUSION INJURY
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LIVER TRANSPLANTATION
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POSTREPERFUSION SYNDROME
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SLPI
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-22T14:56:59Z
dc.journal.volume
31
dc.journal.number
12
dc.journal.pagination
1357-1368
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Casciato, Paola. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ambrosi, Nella Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Caro, Fiorella Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Vazquez, Mónica. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Müllen, Eduardo. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Gadano, Adrián Carlos. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: de Santibanes, Eduardo. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: de Santibañes, Martin. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Zandomeni, Marcos. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Chahdi, Magali. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Lazarte, Julio C.. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Biagiola, David A.. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Iaquinandi, Juan Cruz. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Santofimia-Castaño, Patricia. Centre de Recherche En Cancerologie de Marseille; Francia
dc.description.fil
Fil: Iovanna, Juan Lucio. Centre de Recherche En Cancerologie de Marseille; Francia
dc.description.fil
Fil: Incardona, Claudio. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina. Fundación Gador; Argentina
dc.description.fil
Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.journal.title
Transplant International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13314
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/tri.13314
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