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dc.contributor.author
Sarati, Lorena Ivonne
dc.contributor.author
Toblli, Jorge Eduardo
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Martinez, Carla Romina
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Uceda, Ana Margarita
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Feldman, Mariana Laura
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Balaszczuk, Ana Maria
dc.contributor.author
Fellet, Andrea L.
dc.date.available
2019-10-01T20:50:11Z
dc.date.issued
2013-09
dc.identifier.citation
Sarati, Lorena Ivonne; Toblli, Jorge Eduardo; Martinez, Carla Romina; Uceda, Ana Margarita; Feldman, Mariana Laura; et al.; Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis; W B Saunders Co-Elsevier Inc; Metabolism-clinical And Experimental; 62; 9; 9-2013; 1287-1295
dc.identifier.issn
0026-0495
dc.identifier.uri
http://hdl.handle.net/11336/84987
dc.description.abstract
Objective Hypothyroid state and aging are associated with impairment in water reabsorption and changes in aquaporin water channel type 2 (AQP2). Nitric oxide (NO) is involved in AQP2 trafficking to the apical plasma membrane in medullary collecting duct cells. The purpose of this study was to investigate whether aging and hypothyroidism alter renal function, and whether medullary NO and AQP2 are implicated in maintaining water homeostasis. Materials/Methods Sprague-Dawley rats aged 2 and 18 months old were treated with 0.02% methimazole (w/v) during 28 days. Renal function was examined and NO synthase (NOS) activity ([14C (U)]-L-arginine to [14C (U)]-L-citrulline assays), NOS, caveolin-1 and -3 and AQP2 protein levels were determined in medullary tissue (Western blot). Plasma membrane fraction and intracellular vesicle fraction of AQP2 were evaluated by Western blot and immunohistochemistry. Results A divergent response was observed in hypothyroid rats: while young rats exhibited polyuria with decreased medullary NOS activity, adult rats exhibited a decrease in urine output with increased NOS activity. AQP2 was increased with hypothyroidism, but while young rats exhibited increased AQP2 in plasma membrane, adult rats did so in the cytosolic site. Conclusions Hypothyroidism contributes in a differential way to aging-induced changes in renal function, and medullary NO and AQP2 would be implicated in maintaining water homeostasis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
W B Saunders Co-Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGED
dc.subject
RENAL FUNCTION
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THYROID HORMONES
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WATER CHANNEL
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T21:03:26Z
dc.journal.volume
62
dc.journal.number
9
dc.journal.pagination
1287-1295
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Sarati, Lorena Ivonne. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
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Fil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
dc.description.fil
Fil: Martinez, Carla Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
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Fil: Uceda, Ana Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
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Fil: Feldman, Mariana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
dc.description.fil
Fil: Balaszczuk, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Fellet, Andrea L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.journal.title
Metabolism-clinical And Experimental
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0026049513001303
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.metabol.2013.04.013
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