Mostrar el registro sencillo del ítem
dc.contributor.author
Di Savino, Augusta
dc.contributor.author
Panuzzo, Cristina
dc.contributor.author
Rocca, Stefania
dc.contributor.author
Familiari, Ubaldo
dc.contributor.author
Piazza, Rocco
dc.contributor.author
Crivellaro, Sabrina
dc.contributor.author
Carrà, Giovanna
dc.contributor.author
Ferretti, Roberta
dc.contributor.author
Fusella, Federica
dc.contributor.author
Giugliano, Emilia
dc.contributor.author
Camporeale, Annalisa
dc.contributor.author
Franco, Irene
dc.contributor.author
Miniscalco, Barbara
dc.contributor.author
Cutrin, Juan Carlos
dc.contributor.author
Turco, Emilia
dc.contributor.author
Silengo, Lorenzo
dc.contributor.author
Hirsch, Emilio
dc.contributor.author
Rege Cambrin, Giovanna
dc.contributor.author
Gambacorti Passerin, Carlo
dc.contributor.author
Pandolfi, Pier Paolo
dc.contributor.author
Papotti, Mauro
dc.contributor.author
Saglio, Giuseppe
dc.contributor.author
Tarone, Guido
dc.contributor.author
Morotti, Alessandro
dc.contributor.author
Brancaccio, Mara
dc.date.available
2016-11-01T21:45:59Z
dc.date.issued
2015-04
dc.identifier.citation
Di Savino, Augusta; Panuzzo, Cristina; Rocca, Stefania; Familiari, Ubaldo; Piazza, Rocco; et al.; Morgana acts as an oncosuppressor in chronic myeloid leukemia; American Society Of Hematology; Blood, The Journal Of The American Society Of Hematology - Print; 125; 4-2015; 2245-2253
dc.identifier.issn
0006-4971
dc.identifier.uri
http://hdl.handle.net/11336/7914
dc.description.abstract
We recently described morgana as an essential protein able to regulate centrosome du- plication and genomic stability, by inhibiting ROCK. Here we show that morgana 1/2 mice spontaneously develop a lethal myeloproliferative disease resembling human atypical chronic myeloid leukemia (aCML), preceded by ROCK hyperactivation, centrosome am- plification, and cytogenetic abnormalities in the bone marrow (BM). Moreover, we found that morgana is underexpressed in the BM of patients affected by atypical CML, a disorder of poorly understood molecular basis, characterized by nonrecurrent cytogenetic abnormalities. Morgana is also underexpressed in the BM of a portion of patients affected by Philadelphia-positive CML (Ph1 CML) caused by the BCR-ABL oncogene, and in this condition, morgana underexpression predicts a worse response to imatinib, the standard treatment for Ph1 CML. Thus, morgana acts as an oncosuppressor with different modalities: (1) Morgana underexpression induces centrosome amplifi- cation and cytogenetic abnormalities, and (2) in Ph1 CML, it synergizes with BCR-ABL signaling, reducing the efficacy of imatinib treatment. Importantly, ROCK inhibitionin the BM of patients underexpressing morgana restored the efficacy of imatinib to induce apoptosis, suggesting that ROCK inhibitors, combined with imatinib treatment, can overcome suboptimal responses in patients in which morgana is underex- pressed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society Of Hematology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Morgana
dc.subject
Centrosome
dc.subject
Chronic Myeloid Leukemia
dc.subject
Rock Inhibitors
dc.subject.classification
Hematología
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Morgana acts as an oncosuppressor in chronic myeloid leukemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:12:13Z
dc.journal.volume
125
dc.journal.pagination
2245-2253
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Di Savino, Augusta. Universitã â Di Torino; Italia
dc.description.fil
Fil: Panuzzo, Cristina. Universitã â Di Torino; Italia
dc.description.fil
Fil: Rocca, Stefania. Universitã â Di Torino; Italia
dc.description.fil
Fil: Familiari, Ubaldo. Universitã â Di Torino; Italia
dc.description.fil
Fil: Piazza, Rocco. Universita Degli Studi Di Milano; Italia
dc.description.fil
Fil: Crivellaro, Sabrina. Universitã â Di Torino; Italia
dc.description.fil
Fil: Carrà, Giovanna. Universitã â Di Torino; Italia
dc.description.fil
Fil: Ferretti, Roberta. Universitã â Di Torino; Italia
dc.description.fil
Fil: Fusella, Federica. Universitã â Di Torino; Italia
dc.description.fil
Fil: Giugliano, Emilia. Universitã â Di Torino; Italia
dc.description.fil
Fil: Camporeale, Annalisa. Universitã â Di Torino; Italia
dc.description.fil
Fil: Franco, Irene. Universitã â Di Torino; Italia
dc.description.fil
Fil: Miniscalco, Barbara. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Cutrin, Juan Carlos. Universitã â Di Torino; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Turco, Emilia. Universita di Torino; Italia
dc.description.fil
Fil: Silengo, Lorenzo. Universita di Torino; Italia
dc.description.fil
Fil: Hirsch, Emilio. Universita di Torino; Italia
dc.description.fil
Fil: Rege Cambrin, Giovanna. Universita di Torino; Italia
dc.description.fil
Fil: Gambacorti Passerin, Carlo. Universita Degli Studi Di Milano; Italia
dc.description.fil
Fil: Pandolfi, Pier Paolo. Universita di Torino; Italia. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Papotti, Mauro. Universita di Torino; Italia
dc.description.fil
Fil: Saglio, Giuseppe. Universita di Torino; Italia
dc.description.fil
Fil: Tarone, Guido. Universita di Torino; Italia
dc.description.fil
Fil: Morotti, Alessandro. Universita di Torino; Italia
dc.description.fil
Fil: Brancaccio, Mara. Universita di Torino; Italia
dc.journal.title
Blood, The Journal Of The American Society Of Hematology - Print
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/125/14/2245.long?sso-checked=true
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1182/blood-2014-05-575001
Archivos asociados