Mostrar el registro sencillo del ítem
dc.contributor.author
Arias, Juan Marcelo
dc.contributor.author
Tuttolomondo, María Eugenia
dc.contributor.author
Díaz, Sonia Beatriz
dc.contributor.author
Ben Altabef, Aída
dc.date.available
2019-06-10T12:18:06Z
dc.date.issued
2015-03
dc.identifier.citation
Arias, Juan Marcelo; Tuttolomondo, María Eugenia; Díaz, Sonia Beatriz; Ben Altabef, Aída; FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states; Wiley; J. Raman Spectroscopy; 46; 4; 3-2015; 369-376
dc.identifier.issn
1097-4555
dc.identifier.uri
http://hdl.handle.net/11336/77843
dc.description.abstract
Interactions of L-cysteine ethyl ester hydrochloride (CE), a bioactive cysteine derivative, with dipalmitoylphosphatidylcholine (DPPC) were investigated. To gain a deeper insight into analyzing L-cysteine ethyl ester HCl interaction with liposomes of DPPC in anhydrous and hydrated states, we performed experimental studies by infrared (Fourier transform infrared spectroscopy) and Raman spectroscopies. The results revealed that the interaction of CE with the phospholipid head groups was the same in absence or presence of water. In both states, the wavenumber of the PO2 group and C?N bond of the choline group decreased. This behavior can be ascribed to the replacement of hydration water and binding to the phosphate group. In the Raman spectrum results for the anhydrous and gel states, the S?H stretching band of the CE shifted to lower frequencies with a decrease in its force constant. Biologically active lipophilicmolecules such as CE should be studied in terms of their interaction with lipid bilayers prior to the development of advanced lipid carrier systems such as liposomes. The results of these studies provide information onmembrane integrity and physicochemical properties that are essential for the rational design of lipidic drug delivery systems.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Raman
dc.subject
Ftir
dc.subject
Dppc Bilayers
dc.subject
Phospholipid Hydrations
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-04T16:03:33Z
dc.journal.volume
46
dc.journal.number
4
dc.journal.pagination
369-376
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Arias, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.description.fil
Fil: Tuttolomondo, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.description.fil
Fil: Díaz, Sonia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.description.fil
Fil: Ben Altabef, Aída. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.journal.title
J. Raman Spectroscopy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/jrs.4659
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jrs.4659
Archivos asociados