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dc.contributor.author
García, Lucila
dc.contributor.author
Veiga, Maria Florencia
dc.contributor.author
Lustig, Livia
dc.contributor.author
Vazquez, Monica Hebe
dc.contributor.author
Veaute, Carolina Melania Isabel
dc.date.available
2019-05-31T18:25:36Z
dc.date.issued
2012-07
dc.identifier.citation
García, Lucila; Veiga, Maria Florencia; Lustig, Livia; Vazquez, Monica Hebe; Veaute, Carolina Melania Isabel; DNA Immunization Against Proacrosin Impairs Fertility in Male Mice; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 68; 1; 7-2012; 56-67
dc.identifier.issn
1046-7408
dc.identifier.uri
http://hdl.handle.net/11336/77476
dc.description.abstract
Problem: Evaluation of proacrosin/acrosin ability to induce an immune response in male mice after genetic immunization and assessment of animal fertility. Method of study: Mice received 50 μg per animal of a plasmid containing the human proacrosin cDNA (pSF2-Acro) (control: empty plasmid, pSF2). The humoral response was evaluated by ELISA and immunocytochemistry. In vivo fertility was assessed by mating immunized males with control females. The effect of antibodies upon Ca +2-ionophore-induced acrosomal exocytosis (AE) and in vitro sperm-zona pellucida (ZP) binding was also studied. Results: pSF2-Acro-immunized mice developed high levels of specific antibodies (P < 0.05) that recognized the sperm acrosomal cap. The number of fertile mice was lower (P = 0.027) in pSF2-Acro-immunized animals than in controls. Litter size was smaller (P < 0.05) in the pSF2-Acro group compared with controls. A negative correlation (P < 0.05) between antibody levels and litter size was found. Antiproacrosin/acrosin antibodies inhibited sperm-ZP binding (P < 0.0001) and Ca +2-ionophore-induced AE (P < 0.05). Conclusion: DNA immunization against proacrosin elicits an immune response in male mice associated with abnormal sperm functions and reduced fertility. © 2012 John Wiley & Sons A/S.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acrosomal Exocytosis
dc.subject
Fertilization
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Genetic Immunization
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Infertility
dc.subject
Proacrosin/Acrosin
dc.subject
Sperm Antigen
dc.subject
Zona Pellucida
dc.subject.classification
Tecnologías que involucran la identificación de ADN, proteínas y enzimas, y cómo influyen en el conjunto de enfermedades y mantenimiento del bienestar
dc.subject.classification
Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
DNA Immunization Against Proacrosin Impairs Fertility in Male Mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-14T17:49:34Z
dc.journal.volume
68
dc.journal.number
1
dc.journal.pagination
56-67
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: García, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Veiga, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Veaute, Carolina Melania Isabel. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
dc.journal.title
American Journal of Reproductive Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0897.2012.01127.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/j.1600-0897.2012.01127.x
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