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dc.contributor.author
Ortells, Marcelo Oscar
dc.date.available
2019-04-22T21:14:28Z
dc.date.issued
2016-01
dc.identifier.citation
Ortells, Marcelo Oscar; Structure and function development during evolution of pentameric ligand gated ion channels; Smart Science and Technology; Neurotransmitter; 3; 1-2016; 1-12
dc.identifier.issn
2375-2440
dc.identifier.uri
http://hdl.handle.net/11336/74754
dc.description.abstract
Ligand Gated Ion Channels (LGICs) are receptors widely involved in vertebrate neuronal and non-neuronal signalling as well as muscle activation. Until very recently these receptors, were only known to exist in animal cells and were named the Cys-loop receptor superfamily because they all share this sub-substructure in their amino acid sequences. Nowadays, these receptors are known as "pentameric" LGICs (pLGICs), to differentiate from other LGICs such us tetrameric glutamate or trimeric ATP LGICs. The first phylogenetic analyses of pLGICs have been performed almost 20 years ago, where only eukaryotic members were known. Currently, we have many more sequences from invertebrate species, but most importantly, we know that these receptors are present in a variety of prokaryotic organisms, a fact predicted in those early studies. Equally important, we have information about the tertiary and quaternary structures from prokaryotic to eukaryotic members, which enlightened our evolutionary understanding of these fascinating and functionally important proteins. Surprisingly, the prokaryotic receptors lack the Cys-loop characteristic of eukaryote receptors which once gave the name to the superfamily. This review focuses on the history of the evolutionary processes of these receptors involved in very important physiological functions as well as in many diseases such as tobacco addiction and schizophrenia, to name just a few.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Smart Science and Technology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Assembly
dc.subject
Desensitization
dc.subject
Nicotinic Receptors
dc.subject
Phylogenetics
dc.subject
Plgics
dc.subject
Receptor Evolution
dc.subject
Structure Evolution
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Structure and function development during evolution of pentameric ligand gated ion channels
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-22T13:59:32Z
dc.journal.volume
3
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Houston
dc.description.fil
Fil: Ortells, Marcelo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Morón. Facultad de Medicina; Argentina
dc.journal.title
Neurotransmitter
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.smartscitech.com/index.php/NT/article/view/1273/pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.14800/nt.1273
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.smartscitech.com/index.php/NT/article/view/1273
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