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dc.contributor.author
Filippa, Veronica Palmira
dc.contributor.author
Godoy, Daiana
dc.contributor.author
Perez, Edith
dc.contributor.author
Mohamed, Fabian
dc.date.available
2016-08-29T20:28:43Z
dc.date.issued
2014-08
dc.identifier.citation
Filippa, Veronica Palmira; Godoy, Daiana; Perez, Edith; Mohamed, Fabian; Effects of castration on androgen receptors and gonadotropins in the pituitary of adult male viscachas; Csiro Publishing; Reproduction Fertility And Development; 26; 7; 8-2014; 991-1000
dc.identifier.issn
1031-3613
dc.identifier.uri
http://hdl.handle.net/11336/7343
dc.description.abstract
The aims of the present study were to determine whether castration results in quantitative immunohistochemical changes in androgen receptors (AR), LH-immunoreactive (IR) cells and FSH-IR cells, and to analyse the colocalisation of AR and gonadotropins in the pituitary pars distalis (PD) of viscachas. Pituitaries were processed for light and electron microscopy. AR-IR, LH-IR and FSH-IR cells were detected by immunohistochemistry. In morphometric studies, the percentage of AR-IR, LH-IR, FSH-IR, LH-IR/AR-IR and FSH-IR/AR-IR cells was determined. In intact viscachas, AR were distributed throughout the PD; they were numerous at the caudal end, with intense immunostaining. LH-IR cells and FSH-IR cells were found mainly in the ventral region and at the rostral end of the PD. Approximately 45%-66% of LH-IR cells and 49%-57% of FSH-IR cells expressed AR in the different zones of the PD. In castrated viscachas, there was a significant decrease in the percentage of AR-IR, LH-IR, FSH-IR, and FSH-IR/AR-IR cells. Some pituitary cells from castrated viscachas also exhibited ultrastructural changes. These results provide morphological evidence that gonadal androgens are directly related to the immunolabelling of AR, LH and FSH. Moreover, the colocalisation of AR and FSH is most affected by castration, suggesting the existence of a subpopulation of gonadotrophs with different regulatory mechanisms for hormonal synthesis, storage and secretion.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Csiro Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lagostomus
dc.subject
Androgen
dc.subject
Receptor
dc.subject
Gonadotrophs
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of castration on androgen receptors and gonadotropins in the pituitary of adult male viscachas
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-04T17:23:51Z
dc.journal.volume
26
dc.journal.number
7
dc.journal.pagination
991-1000
dc.journal.pais
Australia
dc.journal.ciudad
Collingwood
dc.description.fil
Fil: Filippa, Veronica Palmira. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Area Ecológica; Argentina
dc.description.fil
Fil: Godoy, Daiana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Perez, Edith. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Mohamed, Fabian. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.journal.title
Reproduction Fertility And Development
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.publish.csiro.au/?paper=RD13126
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1071/RD13126
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