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dc.contributor.author
Rivulgo, Virginia Margarita
dc.contributor.author
Sparo, Mónica
dc.contributor.author
Ceci, Mónica
dc.contributor.author
Fumuso, Elida
dc.contributor.author
Confalonieri, Alejandra
dc.contributor.author
Delpech, Gastón
dc.contributor.author
Sanchez Bruni, Sergio Fabian
dc.date.available
2016-08-29T19:34:56Z
dc.date.issued
2013-09
dc.identifier.citation
Rivulgo, Virginia Margarita; Sparo, Mónica; Ceci, Mónica; Fumuso, Elida; Confalonieri, Alejandra; et al.; Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study; Hindawi Publishing Corporation; Biomed Central International; 2013; 9-2013; 392010-392010
dc.identifier.issn
2314-6141
dc.identifier.uri
http://hdl.handle.net/11336/7339
dc.description.abstract
Azithromycin(AZM)therapeutic failure and relapses of patients treated with generic -35 formulations have been observed in clinical practice.The main goal of this research was 36 to compare in a pre-clinical study the serum exposure and lung tissue concentrationof 37 two commercial formulations AZM-based in murine model. The current study involved 38 264 healthy Balb-C.Mice were divided in two groups (n=44): Animals of Group A 39 (Reference Formulation ?R-) were orally treated with AZM suspension at 10 mg/kg of 40 b.w.Experimental animals of Group B (Generic formulation ?G-) received identical 41 treatment than Group A with a generic formulation AZM-based.The study was repeated 42 twice as Phase II and III. Serum and lung tissue samples were taken 24 hpost treatment.43 Validated microbiological assay was used to determine the serum pharmacokinetic and 44 lung distribution of AZM.45 After the pharmacokinetic analysis was observed a similar serum exposure for both46 formulations of AZM assayed. In contrast, statistical differences (p< 0.001)were 47 obtained after comparing the concentrations of both formulations in lung tissue, being48 the values obtained for AUC and Cmax (AZM-R-)+1586 and 122%respectively,than 49 those obtained for AZM-G-in lung. These differences may indicate large differences on 50 the distribution process of both formulations, which may explain the lack of 51 efficacy/therapeutic failure observed on clinical practice.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Azithromycin
dc.subject
Generics
dc.subject
Mice
dc.subject
Lung
dc.subject
Pharmacokinetics
dc.subject.classification
Otras Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-04T18:19:56Z
dc.journal.volume
2013
dc.journal.pagination
392010-392010
dc.journal.pais
Egipto
dc.journal.ciudad
El Cairo
dc.description.fil
Fil: Rivulgo, Virginia Margarita. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Sparo, Mónica. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Ceci, Mónica. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Fumuso, Elida. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Confalonieri, Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Delpech, Gastón. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.journal.title
Biomed Central International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/bmri/2013/392010/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2013/392010
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