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dc.contributor.author
Boulanger Weill, Jonathan
dc.contributor.author
Coste, Virginie
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Jouary, Adrien
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Romano, Sebastián Alejo
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Pérez Schuster, Verónica
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Sumbre, Germán
dc.date.available
2018-11-27T15:12:44Z
dc.date.issued
2017-06-19
dc.identifier.citation
Boulanger Weill, Jonathan; Coste, Virginie; Jouary, Adrien; Romano, Sebastián Alejo; Pérez Schuster, Verónica; et al.; Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits; Cell Press; Current Biology; 27; 12; 19-6-2017; 1707-1720.e5
dc.identifier.issn
0960-9822
dc.identifier.uri
http://hdl.handle.net/11336/65309
dc.description.abstract
From development up to adulthood, the vertebrate brain is continuously supplied with newborn neurons that integrate into established mature circuits. However, how this process is coordinated during development remains unclear. Using two-photon imaging, GCaMP5 transgenic zebrafish larvae, and sparse electroporation in the larva's optic tectum, we monitored spontaneous and induced activity of large neuronal populations containing newborn and functionally mature neurons. We observed that the maturation of newborn neurons is a 4-day process. Initially, newborn neurons showed undeveloped dendritic arbors, no neurotransmitter identity, and were unresponsive to visual stimulation, although they displayed spontaneous calcium transients. Later on, newborn-labeled neurons began to respond to visual stimuli but in a very variable manner. At the end of the maturation period, newborn-labeled neurons exhibited visual tuning curves (spatial receptive fields and direction selectivity) and spontaneous correlated activity with neighboring functionally mature neurons. At this developmental stage, newborn-labeled neurons presented complex dendritic arbors and neurotransmitter identity (excitatory or inhibitory). Removal of retinal inputs significantly perturbed the integration of newborn neurons into the functionally mature tectal network. Our results provide a comprehensive description of the maturation of newborn neurons during development and shed light on potential mechanisms underlying their integration into a functionally mature neuronal circuit.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neurogenesis
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Newborn Neurons
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Optic Tectum
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Optogenetics
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Two-Photon Calcium Imaging
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Visual System
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Zebrafish
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T18:09:06Z
dc.journal.volume
27
dc.journal.number
12
dc.journal.pagination
1707-1720.e5
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Boulanger Weill, Jonathan. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Coste, Virginie. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Jouary, Adrien. Ecole Normale Supérieure; Francia
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Fil: Romano, Sebastián Alejo. Ecole Normale Supérieure; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
dc.description.fil
Fil: Pérez Schuster, Verónica. Ecole Normale Supérieure; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
dc.description.fil
Fil: Sumbre, Germán. Ecole Normale Supérieure; Francia
dc.journal.title
Current Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960982217305651
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cub.2017.05.029
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