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dc.contributor.author
Cittadini, María Cecilia  
dc.contributor.author
García Estévez, Ignacio  
dc.contributor.author
Escribano Bailón, M. Teresa  
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Rivas Gonzalo, Julián C.  
dc.contributor.author
Valentich, Mirta Ana  
dc.contributor.author
Repossi Marquez, Pablo Gaston  
dc.contributor.author
Soria, Elio Andres  
dc.date.available
2018-11-07T18:36:12Z  
dc.date.issued
2018-02-21  
dc.identifier.citation
Cittadini, María Cecilia; García Estévez, Ignacio; Escribano Bailón, M. Teresa; Rivas Gonzalo, Julián C.; Valentich, Mirta Ana; et al.; Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds; Lawrence Erlbaum Assoc Inc-taylor & Francis; Nutrition And Cancer; 70; 2; 21-2-2018; 267-277  
dc.identifier.issn
0163-5581  
dc.identifier.uri
http://hdl.handle.net/11336/63908  
dc.description.abstract
Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Lawrence Erlbaum Assoc Inc-taylor & Francis  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Fatty Acids  
dc.subject
Interleukin-6  
dc.subject
Glioma Cells  
dc.subject
Ilex Paraguariensis  
dc.subject
Phenolic Compounds  
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Aspidosperma Quebracho-Blanco  
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Lantana Grisebachii  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Medicina Critica y de Emergencia  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Salud Ocupacional  
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Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-22T18:58:37Z  
dc.journal.volume
70  
dc.journal.number
2  
dc.journal.pagination
267-277  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Ministerio de Salud; Argentina  
dc.description.fil
Fil: García Estévez, Ignacio. Universidad de Salamanca; España  
dc.description.fil
Fil: Escribano Bailón, M. Teresa. Universidad de Salamanca; España  
dc.description.fil
Fil: Rivas Gonzalo, Julián C.. Universidad de Salamanca; España  
dc.description.fil
Fil: Valentich, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina  
dc.description.fil
Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina  
dc.description.fil
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina  
dc.journal.title
Nutrition And Cancer  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/01635581.2018.1412484  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01635581.2018.1412484