Mostrar el registro sencillo del ítem

dc.contributor.author
Vase, MajaØlholm  
dc.contributor.author
Ludvigsen, Maja  
dc.contributor.author
Bendix, Knud  
dc.contributor.author
Dutoit, Stephen H.  
dc.contributor.author
Hjortebjerg, Rikke  
dc.contributor.author
Petruskevicius, Irma  
dc.contributor.author
Møller, Michael B.  
dc.contributor.author
Pedersen, Gitte  
dc.contributor.author
Denton, Paul W.  
dc.contributor.author
Honoré, Bent  
dc.contributor.author
Rabinovich, Gabriel Adrián  
dc.contributor.author
Larsen, Carsten S.  
dc.contributor.author
D'Amore, Francesco  
dc.date.available
2018-11-05T23:40:22Z  
dc.date.issued
2017-10-23  
dc.identifier.citation
Vase, MajaØlholm; Ludvigsen, Maja; Bendix, Knud; Dutoit, Stephen H.; Hjortebjerg, Rikke; et al.; Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma; Lippincott Williams; Aids; 31; 16; 23-10-2017; 2311-2313  
dc.identifier.issn
0269-9370  
dc.identifier.uri
http://hdl.handle.net/11336/63728  
dc.description.abstract
At AHIV-1 infection, the binding of the viral envelopeproteins to CD4þ is essential for viral transmission, andthis process is facilitated by interaction with the highlyconserved host lectin, galectin-1 (Gal-1) [1?3]. Withinthe tumor microenvironment, Gal-1 is expressed by bothtumor and stromal cells where it promotes tumorimmune escape and favors hypoxia-driven angiogenesis[4?6]. In sporadically occurring Hodgkin lymphoma,high Gal-1 expression at diagnosis is associated withpoorer treatment response [7], and high soluble Gal-1(sGal-1) correlates with adverse disease characteristics [8].Previous studies have shown that targeted inhibition ofGal-1 prevents tumor-induced immunosuppression[9,10] as well as inhibits tumor growth and metastasisin various tumor models [6,11?13].In conclusion, the results of our study indicate that Gal-1 is significantly associated with risk of lymphoma in HIV-infected individuals and may represent an attractive futuretarget for the management of HIV-associated lymphoma.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Lippincott Williams  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Galectin-1  
dc.subject
Hiv  
dc.subject
Lymphoma  
dc.subject
Prognosis  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-30T18:30:43Z  
dc.journal.volume
31  
dc.journal.number
16  
dc.journal.pagination
2311-2313  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Philadelphia  
dc.description.fil
Fil: Vase, MajaØlholm. University Aarhus; Dinamarca  
dc.description.fil
Fil: Ludvigsen, Maja. University Aarhus; Dinamarca  
dc.description.fil
Fil: Bendix, Knud. University Aarhus; Dinamarca  
dc.description.fil
Fil: Dutoit, Stephen H.. University Aarhus; Dinamarca  
dc.description.fil
Fil: Hjortebjerg, Rikke. University Aarhus; Dinamarca  
dc.description.fil
Fil: Petruskevicius, Irma. University Aarhus; Dinamarca  
dc.description.fil
Fil: Møller, Michael B.. Odense Universitetshospital; Dinamarca  
dc.description.fil
Fil: Pedersen, Gitte. Aalborg Universitet; Dinamarca  
dc.description.fil
Fil: Denton, Paul W.. University Aarhus; Dinamarca. Arhus Universitetshospital; Dinamarca  
dc.description.fil
Fil: Honoré, Bent. University Aarhus; Dinamarca  
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina  
dc.description.fil
Fil: Larsen, Carsten S.. Arhus Universitetshospital; Dinamarca  
dc.description.fil
Fil: D'Amore, Francesco. Arhus Universitetshospital; Dinamarca  
dc.journal.title
Aids  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/pubmed?pmid=28991028  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/QAD.0000000000001622  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/28991028