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dc.contributor.author
Dionisio, Leonardo Raul
dc.contributor.author
Caldironi, Hugo Alfredo
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de Rosa, Maria Jose
dc.date.available
2018-10-25T18:58:25Z
dc.date.issued
2017-01-15
dc.identifier.citation
Dionisio, Leonardo Raul; Caldironi, Hugo Alfredo; de Rosa, Maria Jose; Expression and function of non-neuronal GABA transporters in human lymphocytes; Asian Network for Scientific Information; International Journal Of Pharmacology; 13; 2; 15-1-2017; 205-211
dc.identifier.issn
1811-7775
dc.identifier.uri
http://hdl.handle.net/11336/63080
dc.description.abstract
Background: Neurotransmitters not only play a key role in neuronal communication but also coordinate cell functions in non-neuronal cells, such as immune cells. Previous research reported a complete GABAergic system in human lymphocytes. In this study, focus is put on GABA transporters (GATs) and their physiological role during lymphocyte activation. Materials and Methods: Using RT-PCR and [3H]-GABA uptake assays, GAT expression and activity was evaluated under basal conditions and in cells exposed to phytohemagglutinin (PHA) or GABA. To study GAT role, cell proliferation was evaluated by [3H]-thymidine incorporation in the presence of Nipecotic Acid (NA), a GAT inhibitor. Finally, using HPLC GABA levels were analyzed in culture supernatants. Results: In lymphocytes under any condition, at least one GAT subtype was detected. No GAT-3 was found. The PHA and GABA-treatment increased both expression and activity. In addition, GAT blockade inhibited PHA-induced lymphocyte proliferation. The GABA was detected only in PHA-treated cell supernatants, thus indicating GABA secretion at least during proliferation. Conclusion: These findings demonstrate that extraneuronal GATs affect lymphocyte functionality. Characterization of GAT roles in immune response and as a link between nervous system and immune system will provide new therapeutic targets and could help reduce side effects of current therapies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Asian Network for Scientific Information
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gaba
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Gaba Transporters
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Gat Expression
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Lymphocytes
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Neuroimmune Interactions
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Non-Neuronal Tissues
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Pharmacological Modulation
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T-Cell Proliferation
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Expression and function of non-neuronal GABA transporters in human lymphocytes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T17:11:25Z
dc.identifier.eissn
1812-5700
dc.journal.volume
13
dc.journal.number
2
dc.journal.pagination
205-211
dc.journal.pais
Pakistán
dc.journal.ciudad
Faisalabad
dc.description.fil
Fil: Dionisio, Leonardo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Caldironi, Hugo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.journal.title
International Journal Of Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://scialert.net/abstract/?doi=ijp.2017.205.211
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3923/ijp.2017.205.211
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