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dc.contributor.author
Santos, Pablo Sandro Carvalho
dc.contributor.author
Füst, George
dc.contributor.author
Prohászka, Zoltán
dc.contributor.author
Volz, Armin
dc.contributor.author
Horton, Roger
dc.contributor.author
Miretti, Marcos Mateo
dc.contributor.author
Yu, Chack-Yung
dc.contributor.author
Beck, Stephan G.
dc.contributor.author
Uchanska-Ziegler, Barbara
dc.contributor.author
Ziegler, Andreas
dc.date.available
2018-09-26T18:09:10Z
dc.date.issued
2008-12
dc.identifier.citation
Santos, Pablo Sandro Carvalho; Füst, George; Prohászka, Zoltán; Volz, Armin; Horton, Roger; et al.; Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex; Mary Ann Liebert; Genetic Testing; 12; 4; 12-2008; 481-486
dc.identifier.issn
1090-6576
dc.identifier.uri
http://hdl.handle.net/11336/60931
dc.description.abstract
Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971T) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a 97Thr→Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971T allele (p=1.05×10-2), with higher significance than with A1-B8-DR3 (p=2.38×10-2). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971T polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women. © Copyright 2008, Mary Ann Liebert, Inc. 2008.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hla Haplotype
dc.subject
Smoking
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-18T14:05:06Z
dc.journal.volume
12
dc.journal.number
4
dc.journal.pagination
481-486
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Santos, Pablo Sandro Carvalho. Charité – Universitätsmedizin Berlin;
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Fil: Füst, George. Semmelweis Egyetem;
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Fil: Prohászka, Zoltán. Magyar Tudomanyos Akademia; . Semmelweis Egyetem;
dc.description.fil
Fil: Volz, Armin. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Horton, Roger. Wellcome Trust Sanger Institute;
dc.description.fil
Fil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Wellcome Trust Sanger Institute;
dc.description.fil
Fil: Yu, Chack-Yung. Ohio State University; Estados Unidos
dc.description.fil
Fil: Beck, Stephan G.. Ucl Cancer Institute;
dc.description.fil
Fil: Uchanska-Ziegler, Barbara. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Ziegler, Andreas. Charité – Universitätsmedizin Berlin;
dc.journal.title
Genetic Testing
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/gte.2008.0029
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