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dc.contributor.author
Garro, Hugo Alejandro  
dc.contributor.author
García, Celina E.  
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Martín, Víctor S.  
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Tonn, Carlos Eugenio  
dc.contributor.author
Pungitore, Carlos Rodolfo  
dc.date.available
2016-05-24T19:06:10Z  
dc.date.issued
2015-01  
dc.identifier.citation
Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-918  
dc.identifier.issn
0960-894X  
dc.identifier.uri
http://hdl.handle.net/11336/5821  
dc.description.abstract
DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Natural Products  
dc.subject
Taq Dna Polymerase Inhibitors  
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6-Epi-Catalpol  
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Sylil Derivatives  
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Verbascoside  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-05-16T20:08:45Z  
dc.journal.volume
25  
dc.journal.number
4  
dc.journal.pagination
914-918  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina  
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Fil: García, Celina E.. Universidad de la Laguna; España  
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Fil: Martín, Víctor S.. Universidad de la Laguna; España  
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Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina  
dc.description.fil
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina  
dc.journal.title
Bioorganic & Medicinal Chemistry Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X14013602  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2014.12.052  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bmcl.2014.12.052  

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