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dc.contributor.author
Hernández Martínez, Salvador
dc.contributor.author
Sánchez Zavaleta, Minerva
dc.contributor.author
Brito, Kevin
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Herrera Ortiz, Antonia
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Ons, Sheila
dc.contributor.author
Noriega, Fernando G.
dc.date.available
2018-06-22T18:55:12Z
dc.date.issued
2017-04
dc.identifier.citation
Hernández Martínez, Salvador; Sánchez Zavaleta, Minerva; Brito, Kevin; Herrera Ortiz, Antonia; Ons, Sheila; et al.; Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses; Public Library of Science; Plos One; 12; 4; 4-2017; 1-21; e0175759
dc.identifier.uri
http://hdl.handle.net/11336/49700
dc.description.abstract
Allatotropins (AT) are neuropeptides with pleotropic functions on a variety of insect tissues. They affect processes such as juvenile hormone biosynthesis, cardiac rhythm, oviduct and hindgut contractions, nutrient absorption and circadian cycle. The present work provides experimental evidence that AT elicits immune responses in two important mosquito disease vectors, Anopheles albimanus and Aedes aegypti. Hemocytes and an immune-competent mosquito cell line responded to AT by showing strong morphological changes and increasing bacterial phagocytic activity. Phenoloxidase activity in hemolymph was also increased in Ae. aegypti mosquitoes treated with AT but not in An. albimanus, suggesting differences in the AT-dependent immune activation in the two species. In addition, two important insect immune markers, nitric oxide levels and expression of antimicrobial peptide genes, were increased in An. albimanus guts after AT treatment. AT conjugated to quantum dot nanocrystals (QDots) specifically labeled hemocytes in vivo in both mosquito species, implying molecular interactions between AT and hemocytes. The results of our studies suggest a new role for AT in the modulation of the immune response in mosquitoes.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aedes Aegypti
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Insect
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Anopheles Albimanus
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Neuroendocrinology
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-21T12:57:33Z
dc.identifier.eissn
1932-6203
dc.journal.volume
12
dc.journal.number
4
dc.journal.pagination
1-21; e0175759
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Hernández Martínez, Salvador. Instituto Nacional de Salud Pública; México
dc.description.fil
Fil: Sánchez Zavaleta, Minerva. Instituto Nacional de Salud Pública; México
dc.description.fil
Fil: Brito, Kevin. Instituto Nacional de Salud Pública; México
dc.description.fil
Fil: Herrera Ortiz, Antonia. Instituto Nacional de Salud Pública; México
dc.description.fil
Fil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Noriega, Fernando G.. Florida International University; Estados Unidos
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0175759
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175759
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