Artículo
Adult neurogenesis and the plasticity of the dentate gyrus network
Fecha de publicación:
03/2011
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
European Journal of Neurosciences
ISSN:
0953-816X
e-ISSN:
1460-9568
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The granule cell layer (GCL) of the dentate gyrus contains neurons generated during embryonic, early postnatal and adult life. During adulthood there is a continuous production of neuronal cohorts that develop and functionally integrate in the preexisting circuits. This morphogenic process generates a stratified GCL, with the outermost layers containing dentate granule cells (DGCs) generated during perinatal life, and the innermost layers containing adult-born DGCs. In this review we analyse the functional profile of the different neuronal populations of the GCL, with an emphasis on adult-born neurons as they develop, mature and integrate in the dentate gyrus network. We focus on the contribution of adult-born neurons to activity-dependent synaptic modification in the dentate gyrus and, in turn, discuss how network activity modulates integration and survival of new neurons.
Palabras clave:
Hippocampus
,
Adult Neurogenesis
,
Synaptic Plasticity
,
Neuronal Development
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Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Mongiat, Lucas Alberto; Schinder, Alejandro Fabián; Adult neurogenesis and the plasticity of the dentate gyrus network; Wiley Blackwell Publishing, Inc; European Journal of Neurosciences; 33; 6; 3-2011; 1055-1061
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