Artículo
Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb.
Fecha de publicación:
01/2003
Editorial:
Springer/Plenum Publishers
Revista:
Neurochemical Research
ISSN:
0364-3190
e-ISSN:
1573-6903
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) are involved in growth of neurons. In the rat olfactory epithelium, we previously showed IGF-IR immunostaining in subsets of olfactory receptor neurons. We now report that IGF-IR staining was heaviest in the olfactory nerve layer of the rat olfactory bulb at embryonic days 18, and 19 and postnatal day 1, with labeling of protoglomeruli. In the adult, only a few glomeruli were IGF-IR-positive, some of which were unusually small and strongly labeled. Some IGF-IR-positive fibers penetrated deeper into the external plexiform layer, even in adults. In developing tissues, IGF-IR staining co-localized with that for olfactory marker protein and growth associated protein GAP-43, but to a lesser extent with synaptophysin. In the adult, IGF-IR-positive fibers were compartmentalized within glomeruli. IGF-I may play a role in glomerular synaptogenesis and/or plasticity, possibly contributing to development of coding patterns for odor detection or identification.
Palabras clave:
Olfactory Bulb
,
Igf-1r
,
Olfactory Majker Protein
,
Synaptophysin
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Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Ferrari, Carina Cintia; Johnson, Brett A.; Leon, Michael; Pixley, Sarah K.; Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb.; Springer/Plenum Publishers; Neurochemical Research; 28; 1; 1-2003; 29-43
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