Artículo
Gene therapy for autoimmune diseases: quo vadis?
Fecha de publicación:
10/2004
Editorial:
Nature Publishing Group
Revista:
Nature Reviews Immunology
ISSN:
1474-1733
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
Palabras clave:
Gene
,
Therapy
,
Cancer
,
Autoimmunity
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Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Chernajovsky, Yuti; Gould, David J.; Podhajcer, Osvaldo Luis; Gene therapy for autoimmune diseases: quo vadis?; Nature Publishing Group; Nature Reviews Immunology; 4; 10; 10-2004; 800-811
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