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dc.contributor.author Toni, Nicolas
dc.contributor.author Laplagne, Diego Andres
dc.contributor.author Zhao, Chunmei
dc.contributor.author Lombardi, María Gabriela
dc.contributor.author Ribak, Charles E.
dc.contributor.author Gage, Fred H.
dc.contributor.author Schinder, Alejandro Fabián
dc.date.available 2018-04-19T18:22:57Z
dc.date.issued 2008
dc.identifier.citation Toni, Nicolas; Laplagne, Diego Andres; Zhao, Chunmei; Lombardi, María Gabriela; Ribak, Charles E.; et al.; Neurons born in the adult dentate gyrus form functional synapses with target cells; Nature Publishing Group; Nature Neuroscience.; 11; 8; 2008; 901-907
dc.identifier.issn 1097-6256
dc.identifier.uri http://hdl.handle.net/11336/42708
dc.description.abstract Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. By combining retroviral expression of green fluorescent protein in adult-born neurons of the mouse dentate gyrus with immuno-electron microscopy, we found output synapses that were formed by labeled terminals on appropriate target cells in the CA3 area and the hilus. Furthermore, retroviral expression of channelrhodopsin-2 allowed us to light-stimulate newborn granule cells and identify postsynaptic target neurons by whole-cell recordings in acute slices. Our structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.
dc.format application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Action Potentials/drug effects
dc.subject Action Potentials/physiology
dc.subject Action Potentials/radiation effects
dc.subject Animals
dc.title Neurons born in the adult dentate gyrus form functional synapses with target cells
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-04-05T19:24:12Z
dc.identifier.eissn 1546-1726
dc.journal.volume 11
dc.journal.number 8
dc.journal.pagination 901-907
dc.journal.pais Estados Unidos
dc.journal.ciudad New York
dc.description.fil Fil: Toni, Nicolas. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil Fil: Laplagne, Diego Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil Fil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Ribak, Charles E.. University of California at Irvine; Estados Unidos
dc.description.fil Fil: Gage, Fred H.. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.journal.title Nature Neuroscience.
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nn.2156
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nn.2156
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)