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dc.contributor.author
Saiz, Juan Carlos
dc.contributor.author
Martín Acebes, Miguel A.
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Bueno Marí, Rubén
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Salomón, Oscar Daniel
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Villamil Jiménez, Luis Carlos
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Heukelbach, Jorg
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Alencar, Carlos H.
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Armstrong, Paul K.
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Ortiga Carvalho, Tania M.
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Mendez Otero, Rosalia
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Rosado de Castro, Paulo H.
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Pimentel Coelho, Pedro M.
dc.date.available
2018-04-17T16:31:50Z
dc.date.issued
2017-08
dc.identifier.citation
Saiz, Juan Carlos; Martín Acebes, Miguel A.; Bueno Marí, Rubén; Salomón, Oscar Daniel; Villamil Jiménez, Luis Carlos; et al.; Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?; Frontiers Research Foundation; Frontiers in Microbiology; 8; 1554; 8-2017; 1-25
dc.identifier.issn
1664-302X
dc.identifier.uri
http://hdl.handle.net/11336/42270
dc.description.abstract
Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Research Foundation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Favivirus
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Epidemiology
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Microcephaly
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Guillain-Barré Syndrome
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Antivirals
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-04T14:34:24Z
dc.journal.volume
8
dc.journal.number
1554
dc.journal.pagination
1-25
dc.journal.pais
Suiza
dc.journal.ciudad
Lausana
dc.description.fil
Fil: Saiz, Juan Carlos. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
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Fil: Martín Acebes, Miguel A.. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
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Fil: Bueno Marí, Rubén. Laboratorios Lokímica; España
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Fil: Salomón, Oscar Daniel. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Villamil Jiménez, Luis Carlos. Universidad de la Salle; Colombia
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Fil: Heukelbach, Jorg. Universidad Federal de Ceará; Brasil. James Cook University; Australia
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Fil: Alencar, Carlos H.. Universidad Federal de Ceará; Brasil
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Fil: Armstrong, Paul K.. University of Western Australia; Australia
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Fil: Ortiga Carvalho, Tania M.. Universidade Federal do Rio de Janeiro; Brasil
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Fil: Mendez Otero, Rosalia. Universidade Federal do Rio de Janeiro; Brasil
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Fil: Rosado de Castro, Paulo H.. Universidade Federal do Rio de Janeiro; Brasil
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Fil: Pimentel Coelho, Pedro M.. Universidade Federal do Rio de Janeiro; Brasil
dc.journal.title
Frontiers in Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fmicb.2017.01554/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmicb.2017.01554
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