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dc.contributor.author
Vasti, Cecilia
dc.contributor.author
Hertig, Cecilia Margarita
dc.date.available
2016-02-03T20:04:33Z
dc.date.issued
2014-02
dc.identifier.citation
Vasti, Cecilia; Hertig, Cecilia Margarita; The role of the Neuregulin-1/Erbb signaling pathway in cardiac morphogenesis and remodeling; Sociedad Argentina de Fisiología; Physiological mini reviews; 7; 1; 2-2014; 1-13
dc.identifier.issn
1669-5402
dc.identifier.uri
http://hdl.handle.net/11336/3994
dc.description.abstract
Neuregulin-1 (NRG1) signaling through tyrosine kinase receptors erbB2 and erbB4 was revealed essential for cardiac development as mouse mutated in the Nrg1 or either cognate receptors Erbb2 or Erbb4 genes lack the formation of trabeculae at the ventricular wall. Indeed, the injection of the NRG1 active peptide in developing embryos induced trabeculation of the ventricular free wall. The components of the NRG1 pathway have been identified and the cardiac activities are being progressively characterized. An acquired form of dilated cardiomyopathy was evidenced in a subpopulation of breast tumor patients undergoing a combined treatment with antibodies against erbB2 and chemotherapy. In this regard, the cardiomyocyte-specific gene deletion of either erbb2 or erbb4 leads to ventricular dilation in adult mice, providing an experimental model system to examine the NRG1-mediated activities. We reviewed the evidence on the growing field of research for NRG1 signaling in both cardiac morphogenesis and in the postnatal myocardial remodeling.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Fisiología
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neuregulin
dc.subject
Erbb
dc.subject
Antraciclin
dc.subject
Heart
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The role of the Neuregulin-1/Erbb signaling pathway in cardiac morphogenesis and remodeling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Argentina
dc.journal.ciudad
La Plata
dc.description.fil
Fil: Vasti, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
dc.description.fil
Fil: Hertig, Cecilia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
dc.journal.title
Physiological mini reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/61
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/1669-5402
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